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Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei

The human pathogenic parasite Trypanosoma brucei possess both de novo and salvage routes for the biosynthesis of pyrimidine nucleotides. Consequently, they do not require salvageable pyrimidines for growth. Thymidine kinase (TK) catalyzes the formation of dTMP and dUMP and is one of several salvage...

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Detalles Bibliográficos
Autores principales:	Leija, Christopher, Rijo-Ferreira, Filipa, Kinch, Lisa N., Grishin, Nick V., Nischan, Nicole, Kohler, Jennifer J., Hu, Zeping, Phillips, Margaret A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098729/ https://www.ncbi.nlm.nih.gov/pubmed/27820863 http://dx.doi.org/10.1371/journal.ppat.1006010

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