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Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles
Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098748/ https://www.ncbi.nlm.nih.gov/pubmed/27843313 http://dx.doi.org/10.2147/IJN.S107767 |
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author | Ding, Lingling Li, Jiawei Huang, Rui Liu, Zhidong Li, Chunhua Yao, Shaozi Wang, Jinyan Qi, Dongli Li, Nan Pi, Jiaxin |
author_facet | Ding, Lingling Li, Jiawei Huang, Rui Liu, Zhidong Li, Chunhua Yao, Shaozi Wang, Jinyan Qi, Dongli Li, Nan Pi, Jiaxin |
author_sort | Ding, Lingling |
collection | PubMed |
description | Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO(2) nanocarrier. Then, an FA-PEG-TiO(2) nanoparticle (NP) codelivery system loaded with curcumin and salvianolic acid B were prepared by emulsion evaporation–solidification at low temperature. The obtained folate-targeted NPs (FA-NPs) showed more cytotoxicity on MCF7 cells and MDA-MB-231 cells than a nontargeted NP group. Apart from a synergistic anti-breast cancer effect with curcumin, salvianolic acid B protects the cardiovascular system from oxidative injury by the TiO(2) nanocarrier. With coumarin 6 as a fluorescent probe to observe cellular uptake of NPs, the results of in vitro cellular uptake demonstrated FA-NPs exhibited higher cellular uptake and accumulation in MCF7 cells and MDA-MB-231 cells than nontargeted NPs. Then, in vivo biodistribution of NPs was further qualitatively and quantitatively confirmed by in vivo imaging. More importantly, the animal study further suggested that FA-NPs had significantly stronger antitumor effects via receptor-mediated targeted delivery. Consequently, FA-PEG-TiO(2) NPs loaded with curcumin and salvianolic acid B could be a promising drug-delivery system to treat breast cancer. |
format | Online Article Text |
id | pubmed-5098748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50987482016-11-14 Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles Ding, Lingling Li, Jiawei Huang, Rui Liu, Zhidong Li, Chunhua Yao, Shaozi Wang, Jinyan Qi, Dongli Li, Nan Pi, Jiaxin Int J Nanomedicine Original Research Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO(2) nanocarrier. Then, an FA-PEG-TiO(2) nanoparticle (NP) codelivery system loaded with curcumin and salvianolic acid B were prepared by emulsion evaporation–solidification at low temperature. The obtained folate-targeted NPs (FA-NPs) showed more cytotoxicity on MCF7 cells and MDA-MB-231 cells than a nontargeted NP group. Apart from a synergistic anti-breast cancer effect with curcumin, salvianolic acid B protects the cardiovascular system from oxidative injury by the TiO(2) nanocarrier. With coumarin 6 as a fluorescent probe to observe cellular uptake of NPs, the results of in vitro cellular uptake demonstrated FA-NPs exhibited higher cellular uptake and accumulation in MCF7 cells and MDA-MB-231 cells than nontargeted NPs. Then, in vivo biodistribution of NPs was further qualitatively and quantitatively confirmed by in vivo imaging. More importantly, the animal study further suggested that FA-NPs had significantly stronger antitumor effects via receptor-mediated targeted delivery. Consequently, FA-PEG-TiO(2) NPs loaded with curcumin and salvianolic acid B could be a promising drug-delivery system to treat breast cancer. Dove Medical Press 2016-11-02 /pmc/articles/PMC5098748/ /pubmed/27843313 http://dx.doi.org/10.2147/IJN.S107767 Text en © 2016 Ding et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ding, Lingling Li, Jiawei Huang, Rui Liu, Zhidong Li, Chunhua Yao, Shaozi Wang, Jinyan Qi, Dongli Li, Nan Pi, Jiaxin Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles |
title | Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles |
title_full | Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles |
title_fullStr | Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles |
title_full_unstemmed | Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles |
title_short | Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles |
title_sort | salvianolic acid b protects against myocardial damage caused by nanocarrier tio(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified tio(2) nanoparticles |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098748/ https://www.ncbi.nlm.nih.gov/pubmed/27843313 http://dx.doi.org/10.2147/IJN.S107767 |
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