Cargando…

Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles

Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Lingling, Li, Jiawei, Huang, Rui, Liu, Zhidong, Li, Chunhua, Yao, Shaozi, Wang, Jinyan, Qi, Dongli, Li, Nan, Pi, Jiaxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098748/
https://www.ncbi.nlm.nih.gov/pubmed/27843313
http://dx.doi.org/10.2147/IJN.S107767
_version_ 1782465819486191616
author Ding, Lingling
Li, Jiawei
Huang, Rui
Liu, Zhidong
Li, Chunhua
Yao, Shaozi
Wang, Jinyan
Qi, Dongli
Li, Nan
Pi, Jiaxin
author_facet Ding, Lingling
Li, Jiawei
Huang, Rui
Liu, Zhidong
Li, Chunhua
Yao, Shaozi
Wang, Jinyan
Qi, Dongli
Li, Nan
Pi, Jiaxin
author_sort Ding, Lingling
collection PubMed
description Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO(2) nanocarrier. Then, an FA-PEG-TiO(2) nanoparticle (NP) codelivery system loaded with curcumin and salvianolic acid B were prepared by emulsion evaporation–solidification at low temperature. The obtained folate-targeted NPs (FA-NPs) showed more cytotoxicity on MCF7 cells and MDA-MB-231 cells than a nontargeted NP group. Apart from a synergistic anti-breast cancer effect with curcumin, salvianolic acid B protects the cardiovascular system from oxidative injury by the TiO(2) nanocarrier. With coumarin 6 as a fluorescent probe to observe cellular uptake of NPs, the results of in vitro cellular uptake demonstrated FA-NPs exhibited higher cellular uptake and accumulation in MCF7 cells and MDA-MB-231 cells than nontargeted NPs. Then, in vivo biodistribution of NPs was further qualitatively and quantitatively confirmed by in vivo imaging. More importantly, the animal study further suggested that FA-NPs had significantly stronger antitumor effects via receptor-mediated targeted delivery. Consequently, FA-PEG-TiO(2) NPs loaded with curcumin and salvianolic acid B could be a promising drug-delivery system to treat breast cancer.
format Online
Article
Text
id pubmed-5098748
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-50987482016-11-14 Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles Ding, Lingling Li, Jiawei Huang, Rui Liu, Zhidong Li, Chunhua Yao, Shaozi Wang, Jinyan Qi, Dongli Li, Nan Pi, Jiaxin Int J Nanomedicine Original Research Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO(2) nanocarrier. Then, an FA-PEG-TiO(2) nanoparticle (NP) codelivery system loaded with curcumin and salvianolic acid B were prepared by emulsion evaporation–solidification at low temperature. The obtained folate-targeted NPs (FA-NPs) showed more cytotoxicity on MCF7 cells and MDA-MB-231 cells than a nontargeted NP group. Apart from a synergistic anti-breast cancer effect with curcumin, salvianolic acid B protects the cardiovascular system from oxidative injury by the TiO(2) nanocarrier. With coumarin 6 as a fluorescent probe to observe cellular uptake of NPs, the results of in vitro cellular uptake demonstrated FA-NPs exhibited higher cellular uptake and accumulation in MCF7 cells and MDA-MB-231 cells than nontargeted NPs. Then, in vivo biodistribution of NPs was further qualitatively and quantitatively confirmed by in vivo imaging. More importantly, the animal study further suggested that FA-NPs had significantly stronger antitumor effects via receptor-mediated targeted delivery. Consequently, FA-PEG-TiO(2) NPs loaded with curcumin and salvianolic acid B could be a promising drug-delivery system to treat breast cancer. Dove Medical Press 2016-11-02 /pmc/articles/PMC5098748/ /pubmed/27843313 http://dx.doi.org/10.2147/IJN.S107767 Text en © 2016 Ding et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ding, Lingling
Li, Jiawei
Huang, Rui
Liu, Zhidong
Li, Chunhua
Yao, Shaozi
Wang, Jinyan
Qi, Dongli
Li, Nan
Pi, Jiaxin
Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles
title Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles
title_full Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles
title_fullStr Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles
title_full_unstemmed Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles
title_short Salvianolic acid B protects against myocardial damage caused by nanocarrier TiO(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified TiO(2) nanoparticles
title_sort salvianolic acid b protects against myocardial damage caused by nanocarrier tio(2); and synergistic anti-breast carcinoma effect with curcumin via codelivery system of folic acid-targeted and polyethylene glycol-modified tio(2) nanoparticles
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098748/
https://www.ncbi.nlm.nih.gov/pubmed/27843313
http://dx.doi.org/10.2147/IJN.S107767
work_keys_str_mv AT dinglingling salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT lijiawei salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT huangrui salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT liuzhidong salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT lichunhua salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT yaoshaozi salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT wangjinyan salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT qidongli salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT linan salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles
AT pijiaxin salvianolicacidbprotectsagainstmyocardialdamagecausedbynanocarriertio2andsynergisticantibreastcarcinomaeffectwithcurcuminviacodeliverysystemoffolicacidtargetedandpolyethyleneglycolmodifiedtio2nanoparticles