Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication

The Rif1 protein is a negative regulator of DNA replication initiation in eukaryotes. Here we show that budding yeast Rif1 inhibits DNA replication initiation at the rDNA locus. Absence of Rif1, or disruption of its interaction with PP1/Glc7 phosphatase, leads to more intensive rDNA replication. The...

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Detalles Bibliográficos
Autores principales: Shyian, Maksym, Mattarocci, Stefano, Albert, Benjamin, Hafner, Lukas, Lezaja, Aleksandra, Costanzo, Michael, Boone, Charlie, Shore, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098799/
https://www.ncbi.nlm.nih.gov/pubmed/27820830
http://dx.doi.org/10.1371/journal.pgen.1006414

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