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The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013
BACKGROUND: There was a dengue epidemic in several regions of China in 2013. No study has explored the dynamics of dengue transmission between different geographical locations with dengue outbreaks in China. The purpose of the study is to analyze the epidemiological characteristics and to explore th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098828/ https://www.ncbi.nlm.nih.gov/pubmed/27820815 http://dx.doi.org/10.1371/journal.pntd.0005095 |
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author | Sang, Shaowei Wang, Shasha lu, Liang Bi, Peng Lv, Ming Liu, Qiyong |
author_facet | Sang, Shaowei Wang, Shasha lu, Liang Bi, Peng Lv, Ming Liu, Qiyong |
author_sort | Sang, Shaowei |
collection | PubMed |
description | BACKGROUND: There was a dengue epidemic in several regions of China in 2013. No study has explored the dynamics of dengue transmission between different geographical locations with dengue outbreaks in China. The purpose of the study is to analyze the epidemiological characteristics and to explore the dynamic transmission of dengue in China, 2013. METHODOLOGY AND PRINCIPAL FINDINGS: Records of dengue cases of 2013 were obtained from the China Notifiable Disease Surveillance System. Full E-gene sequences of dengue virus detected from the outbreak regions of China were download from GenBank. Geographical Information System and heatmaps were used to describe the epidemiological characteristics. Maximum Likelihood phylogenetic and Bayesian phylogeographic analyses were conducted to explore the dengue dynamic transmission. Yunnan Province and Guangdong Province had the highest imported cases in the 2013 epidemic. In the locations with local dengue transmission, most of imported cases occurred from June to November 2013 while local dengue cases developed from July to December, 2013. There were significant variations for the incidences of dengue, in terms of age distributions, among different geographic locations. However, gender differences were identified in Guangzhou, Foshan and Xishuangbanna. DENV 1–3 were detected in all locations with the disease outbreaks. Some genotypes were detected in more than one locations and more than one genotypes have been detected in several locations. The dengue viruses introduced to outbreak areas were predominantly from Southeast Asia. In Guangdong Province, the phylogeographical results indicated that dengue viruses of DENV 1 were transmitted to neighboring cities Foshan and Zhongshan from Guangzhou city, and then transmitted to Jiangmen city. The virus in DENV 3 was introduced to Guangzhou city, Guangdong Province from Xishuangbanna prefecture, Yunnan Province. CONCLUSIONS: Repeated dengue virus introductions from Southeast Asia and subsequent domestic dengue transmission within different regions may have contributed to the dengue epidemics in China, 2013. |
format | Online Article Text |
id | pubmed-5098828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50988282016-11-15 The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013 Sang, Shaowei Wang, Shasha lu, Liang Bi, Peng Lv, Ming Liu, Qiyong PLoS Negl Trop Dis Research Article BACKGROUND: There was a dengue epidemic in several regions of China in 2013. No study has explored the dynamics of dengue transmission between different geographical locations with dengue outbreaks in China. The purpose of the study is to analyze the epidemiological characteristics and to explore the dynamic transmission of dengue in China, 2013. METHODOLOGY AND PRINCIPAL FINDINGS: Records of dengue cases of 2013 were obtained from the China Notifiable Disease Surveillance System. Full E-gene sequences of dengue virus detected from the outbreak regions of China were download from GenBank. Geographical Information System and heatmaps were used to describe the epidemiological characteristics. Maximum Likelihood phylogenetic and Bayesian phylogeographic analyses were conducted to explore the dengue dynamic transmission. Yunnan Province and Guangdong Province had the highest imported cases in the 2013 epidemic. In the locations with local dengue transmission, most of imported cases occurred from June to November 2013 while local dengue cases developed from July to December, 2013. There were significant variations for the incidences of dengue, in terms of age distributions, among different geographic locations. However, gender differences were identified in Guangzhou, Foshan and Xishuangbanna. DENV 1–3 were detected in all locations with the disease outbreaks. Some genotypes were detected in more than one locations and more than one genotypes have been detected in several locations. The dengue viruses introduced to outbreak areas were predominantly from Southeast Asia. In Guangdong Province, the phylogeographical results indicated that dengue viruses of DENV 1 were transmitted to neighboring cities Foshan and Zhongshan from Guangzhou city, and then transmitted to Jiangmen city. The virus in DENV 3 was introduced to Guangzhou city, Guangdong Province from Xishuangbanna prefecture, Yunnan Province. CONCLUSIONS: Repeated dengue virus introductions from Southeast Asia and subsequent domestic dengue transmission within different regions may have contributed to the dengue epidemics in China, 2013. Public Library of Science 2016-11-07 /pmc/articles/PMC5098828/ /pubmed/27820815 http://dx.doi.org/10.1371/journal.pntd.0005095 Text en © 2016 Sang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sang, Shaowei Wang, Shasha lu, Liang Bi, Peng Lv, Ming Liu, Qiyong The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013 |
title | The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013 |
title_full | The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013 |
title_fullStr | The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013 |
title_full_unstemmed | The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013 |
title_short | The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013 |
title_sort | epidemiological characteristics and dynamic transmission of dengue in china, 2013 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098828/ https://www.ncbi.nlm.nih.gov/pubmed/27820815 http://dx.doi.org/10.1371/journal.pntd.0005095 |
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