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Multiparameter Evaluation of the Heterogeneity of Circulating Tumor Cells Using Integrated RNA In Situ Hybridization and Immunocytochemical Analysis
Circulating tumor cells (CTCs) are routinely identified as cytokeratin (CK)-positive, epithelial cell adhesion molecule (EpCAM)-positive, and CD45-negative and are enriched based on EpCAM. However, there are a number of methodological challenges regarding both isolation and characterization of these...
Autores principales: | Wu, Yongqi, Park, Kyoung-Joo Jenny, Deighan, Clayton, Amaya, Peter, Miller, Brandon, Pan, Quintin, Zborowski, Maciej, Lustberg, Maryam, Chalmers, Jeffery |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099140/ https://www.ncbi.nlm.nih.gov/pubmed/27878106 http://dx.doi.org/10.3389/fonc.2016.00234 |
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