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Cancer-Related Functions and Subcellular Localizations of Septins

Since the initial discovery of septin family GTPases, the understanding of their molecular organization and cellular roles keeps being refined. Septins have been involved in many physiological processes and the misregulation of specific septin gene expression has been implicated in diverse human pat...

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Autores principales: Poüs, Christian, Klipfel, Laurence, Baillet, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099157/
https://www.ncbi.nlm.nih.gov/pubmed/27878118
http://dx.doi.org/10.3389/fcell.2016.00126
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author Poüs, Christian
Klipfel, Laurence
Baillet, Anita
author_facet Poüs, Christian
Klipfel, Laurence
Baillet, Anita
author_sort Poüs, Christian
collection PubMed
description Since the initial discovery of septin family GTPases, the understanding of their molecular organization and cellular roles keeps being refined. Septins have been involved in many physiological processes and the misregulation of specific septin gene expression has been implicated in diverse human pathologies, including neurological disorders and cancer. In this minireview, we focus on the importance of the subunit composition and subcellular localization of septins relevant to tumor initiation, progression, and metastasis. We especially underline the importance of septin polymer composition and of their association with the plasma membrane, actin, or microtubules in cell functions involved in cancer and in resistance to cancer therapies. Through their scaffolding role, their function in membrane compartmentalization or through their protective function against protein degradation, septins also emerge as critical organizers of membrane-associated proteins and of signaling pathways implicated in cancer-associated angiogenesis, apoptosis, polarity, migration, proliferation, and in metastasis. Also, the question as to which of the free monomers, hetero-oligomers, or filaments is the functional form of mammalian septins is raised and the control over their spatial and temporal localization is discussed. The increasing amount of crosstalks identified between septins and cellular signaling mediators reinforces the exciting possibility that septins could be new targets in anti-cancer therapies or in therapeutic strategies to limit drug resistance.
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spelling pubmed-50991572016-11-22 Cancer-Related Functions and Subcellular Localizations of Septins Poüs, Christian Klipfel, Laurence Baillet, Anita Front Cell Dev Biol Cell and Developmental Biology Since the initial discovery of septin family GTPases, the understanding of their molecular organization and cellular roles keeps being refined. Septins have been involved in many physiological processes and the misregulation of specific septin gene expression has been implicated in diverse human pathologies, including neurological disorders and cancer. In this minireview, we focus on the importance of the subunit composition and subcellular localization of septins relevant to tumor initiation, progression, and metastasis. We especially underline the importance of septin polymer composition and of their association with the plasma membrane, actin, or microtubules in cell functions involved in cancer and in resistance to cancer therapies. Through their scaffolding role, their function in membrane compartmentalization or through their protective function against protein degradation, septins also emerge as critical organizers of membrane-associated proteins and of signaling pathways implicated in cancer-associated angiogenesis, apoptosis, polarity, migration, proliferation, and in metastasis. Also, the question as to which of the free monomers, hetero-oligomers, or filaments is the functional form of mammalian septins is raised and the control over their spatial and temporal localization is discussed. The increasing amount of crosstalks identified between septins and cellular signaling mediators reinforces the exciting possibility that septins could be new targets in anti-cancer therapies or in therapeutic strategies to limit drug resistance. Frontiers Media S.A. 2016-11-08 /pmc/articles/PMC5099157/ /pubmed/27878118 http://dx.doi.org/10.3389/fcell.2016.00126 Text en Copyright © 2016 Poüs, Klipfel and Baillet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Poüs, Christian
Klipfel, Laurence
Baillet, Anita
Cancer-Related Functions and Subcellular Localizations of Septins
title Cancer-Related Functions and Subcellular Localizations of Septins
title_full Cancer-Related Functions and Subcellular Localizations of Septins
title_fullStr Cancer-Related Functions and Subcellular Localizations of Septins
title_full_unstemmed Cancer-Related Functions and Subcellular Localizations of Septins
title_short Cancer-Related Functions and Subcellular Localizations of Septins
title_sort cancer-related functions and subcellular localizations of septins
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099157/
https://www.ncbi.nlm.nih.gov/pubmed/27878118
http://dx.doi.org/10.3389/fcell.2016.00126
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