Tau Structures

Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until it...

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Detalles Bibliográficos
Autores principales: Avila, Jesus, Jiménez, Juan S., Sayas, Carmen L., Bolós, Marta, Zabala, Juan C., Rivas, Germán, Hernández, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099159/
https://www.ncbi.nlm.nih.gov/pubmed/27877124
http://dx.doi.org/10.3389/fnagi.2016.00262
Descripción
Sumario:Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger polymers in physiological and pathological situations.

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