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The Indispensable Roles of Microglia and Astrocytes during Brain Development
Glia are essential for brain functioning during development and in the adult brain. Here, we discuss the various roles of both microglia and astrocytes, and their interactions during brain development. Although both cells are fundamentally different in origin and function, they often affect the same...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099170/ https://www.ncbi.nlm.nih.gov/pubmed/27877121 http://dx.doi.org/10.3389/fnhum.2016.00566 |
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author | Reemst, Kitty Noctor, Stephen C. Lucassen, Paul J. Hol, Elly M. |
author_facet | Reemst, Kitty Noctor, Stephen C. Lucassen, Paul J. Hol, Elly M. |
author_sort | Reemst, Kitty |
collection | PubMed |
description | Glia are essential for brain functioning during development and in the adult brain. Here, we discuss the various roles of both microglia and astrocytes, and their interactions during brain development. Although both cells are fundamentally different in origin and function, they often affect the same developmental processes such as neuro-/gliogenesis, angiogenesis, axonal outgrowth, synaptogenesis and synaptic pruning. Due to their important instructive roles in these processes, dysfunction of microglia or astrocytes during brain development could contribute to neurodevelopmental disorders and potentially even late-onset neuropathology. A better understanding of the origin, differentiation process and developmental functions of microglia and astrocytes will help to fully appreciate their role both in the developing as well as in the adult brain, in health and disease. |
format | Online Article Text |
id | pubmed-5099170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50991702016-11-22 The Indispensable Roles of Microglia and Astrocytes during Brain Development Reemst, Kitty Noctor, Stephen C. Lucassen, Paul J. Hol, Elly M. Front Hum Neurosci Neuroscience Glia are essential for brain functioning during development and in the adult brain. Here, we discuss the various roles of both microglia and astrocytes, and their interactions during brain development. Although both cells are fundamentally different in origin and function, they often affect the same developmental processes such as neuro-/gliogenesis, angiogenesis, axonal outgrowth, synaptogenesis and synaptic pruning. Due to their important instructive roles in these processes, dysfunction of microglia or astrocytes during brain development could contribute to neurodevelopmental disorders and potentially even late-onset neuropathology. A better understanding of the origin, differentiation process and developmental functions of microglia and astrocytes will help to fully appreciate their role both in the developing as well as in the adult brain, in health and disease. Frontiers Media S.A. 2016-11-08 /pmc/articles/PMC5099170/ /pubmed/27877121 http://dx.doi.org/10.3389/fnhum.2016.00566 Text en Copyright © 2016 Reemst, Noctor, Lucassen and Hol. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Reemst, Kitty Noctor, Stephen C. Lucassen, Paul J. Hol, Elly M. The Indispensable Roles of Microglia and Astrocytes during Brain Development |
title | The Indispensable Roles of Microglia and Astrocytes during Brain Development |
title_full | The Indispensable Roles of Microglia and Astrocytes during Brain Development |
title_fullStr | The Indispensable Roles of Microglia and Astrocytes during Brain Development |
title_full_unstemmed | The Indispensable Roles of Microglia and Astrocytes during Brain Development |
title_short | The Indispensable Roles of Microglia and Astrocytes during Brain Development |
title_sort | indispensable roles of microglia and astrocytes during brain development |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099170/ https://www.ncbi.nlm.nih.gov/pubmed/27877121 http://dx.doi.org/10.3389/fnhum.2016.00566 |
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