Cargando…

Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study

BACKGROUND: Effective methods for the treatment of reproductive dysfunction are limited. Previous studies have reported that acupuncture can modulate female hormone levels, improve menstrual disorders, alleviate depression and improve pregnancy rates. However, studies of acupuncture for diminished o...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yang, Li, Yanhong, Chen, Ruixue, Cui, Xiaoming, Yu, Jinna, Liu, Zhishun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099178/
https://www.ncbi.nlm.nih.gov/pubmed/27177929
http://dx.doi.org/10.1136/acupmed-2015-011014
_version_ 1782465896308015104
author Wang, Yang
Li, Yanhong
Chen, Ruixue
Cui, Xiaoming
Yu, Jinna
Liu, Zhishun
author_facet Wang, Yang
Li, Yanhong
Chen, Ruixue
Cui, Xiaoming
Yu, Jinna
Liu, Zhishun
author_sort Wang, Yang
collection PubMed
description BACKGROUND: Effective methods for the treatment of reproductive dysfunction are limited. Previous studies have reported that acupuncture can modulate female hormone levels, improve menstrual disorders, alleviate depression and improve pregnancy rates. However, studies of acupuncture for diminished ovarian reserve (DOR) are lacking. OBJECTIVE: To carry out a prospective observational study aimed at assessing the effect of EA on the reproductive hormone levels of patients with DOR seeking fertility support and consider its safety. METHODS: Eligible patients with DOR received EA for 12 weeks: five times a week for 4 weeks followed by three times a week for 8 weeks. The primary outcome was the change in mean follicle-stimulating hormone (FSH) level at week 12. Mean luteinising hormone (LH) and serum oestradiol (E2) levels, FSH/LH ratios and symptom scale scores were simultaneously observed. RESULTS: Twenty-one patients with DOR were included in the final analysis. Mean FSH levels fell from 19.33±9.47 mIU/mL at baseline to 10.58±6.34 mIU/mL at week 12 and 11.25±6.68 mIU/mL at week 24. Change in mean FSH from baseline was −8.75±11.13 mIU/mL at week 12 (p=0.002) and −8.08±9.56 mIU/mL at week 24 (p=0.001). Mean E2 and LH levels, FSH/LH ratios and irritability scores were improved at weeks 12 and/or 24. Approximately 30% patients reported subjective increases in menstrual volume after treatment. CONCLUSIONS: EA may modulate reproductive hormone levels and the effects seem to persist for at least 12 weeks after treatment with no significant side effects. EA may improve the ovarian reserve of patients with DOR, though further research is needed. TRIAL REGISTRATION NUMBER: NCT02229604; Results.
format Online
Article
Text
id pubmed-5099178
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-50991782016-11-14 Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study Wang, Yang Li, Yanhong Chen, Ruixue Cui, Xiaoming Yu, Jinna Liu, Zhishun Acupunct Med Observation BACKGROUND: Effective methods for the treatment of reproductive dysfunction are limited. Previous studies have reported that acupuncture can modulate female hormone levels, improve menstrual disorders, alleviate depression and improve pregnancy rates. However, studies of acupuncture for diminished ovarian reserve (DOR) are lacking. OBJECTIVE: To carry out a prospective observational study aimed at assessing the effect of EA on the reproductive hormone levels of patients with DOR seeking fertility support and consider its safety. METHODS: Eligible patients with DOR received EA for 12 weeks: five times a week for 4 weeks followed by three times a week for 8 weeks. The primary outcome was the change in mean follicle-stimulating hormone (FSH) level at week 12. Mean luteinising hormone (LH) and serum oestradiol (E2) levels, FSH/LH ratios and symptom scale scores were simultaneously observed. RESULTS: Twenty-one patients with DOR were included in the final analysis. Mean FSH levels fell from 19.33±9.47 mIU/mL at baseline to 10.58±6.34 mIU/mL at week 12 and 11.25±6.68 mIU/mL at week 24. Change in mean FSH from baseline was −8.75±11.13 mIU/mL at week 12 (p=0.002) and −8.08±9.56 mIU/mL at week 24 (p=0.001). Mean E2 and LH levels, FSH/LH ratios and irritability scores were improved at weeks 12 and/or 24. Approximately 30% patients reported subjective increases in menstrual volume after treatment. CONCLUSIONS: EA may modulate reproductive hormone levels and the effects seem to persist for at least 12 weeks after treatment with no significant side effects. EA may improve the ovarian reserve of patients with DOR, though further research is needed. TRIAL REGISTRATION NUMBER: NCT02229604; Results. BMJ Publishing Group 2016-10 2016-05-13 /pmc/articles/PMC5099178/ /pubmed/27177929 http://dx.doi.org/10.1136/acupmed-2015-011014 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Observation
Wang, Yang
Li, Yanhong
Chen, Ruixue
Cui, Xiaoming
Yu, Jinna
Liu, Zhishun
Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study
title Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study
title_full Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study
title_fullStr Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study
title_full_unstemmed Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study
title_short Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study
title_sort electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study
topic Observation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099178/
https://www.ncbi.nlm.nih.gov/pubmed/27177929
http://dx.doi.org/10.1136/acupmed-2015-011014
work_keys_str_mv AT wangyang electroacupunctureforreproductivehormonelevelsinpatientswithdiminishedovarianreserveaprospectiveobservationalstudy
AT liyanhong electroacupunctureforreproductivehormonelevelsinpatientswithdiminishedovarianreserveaprospectiveobservationalstudy
AT chenruixue electroacupunctureforreproductivehormonelevelsinpatientswithdiminishedovarianreserveaprospectiveobservationalstudy
AT cuixiaoming electroacupunctureforreproductivehormonelevelsinpatientswithdiminishedovarianreserveaprospectiveobservationalstudy
AT yujinna electroacupunctureforreproductivehormonelevelsinpatientswithdiminishedovarianreserveaprospectiveobservationalstudy
AT liuzhishun electroacupunctureforreproductivehormonelevelsinpatientswithdiminishedovarianreserveaprospectiveobservationalstudy