Pleiotropic roles of metallothioneins as regulators of chondrocyte apoptosis and catabolic and anabolic pathways during osteoarthritis pathogenesis

OBJECTIVE: The zinc-ZIP8-MTF1 axis induces metallothionein (MT) expression and is a catabolic regulator of experimental osteoarthritis (OA) in mice. The main aim of the current study was to explore the roles and underlying molecular mechanisms of MTs in OA pathogenesis. METHODS: Experimental OA in m...

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Detalles Bibliográficos
Autores principales: Won, Yoonkyung, Shin, Youngnim, Chun, Churl-Hong, Cho, Yongsik, Ha, Chul-Won, Kim, Jin-Hong, Chun, Jang-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099198/
https://www.ncbi.nlm.nih.gov/pubmed/26903440
http://dx.doi.org/10.1136/annrheumdis-2015-208406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099198/
https://www.ncbi.nlm.nih.gov/pubmed/26903440
http://dx.doi.org/10.1136/annrheumdis-2015-208406

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