Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures

This paper shows that the effects of causal SNPs on lifespan, estimated through GWAS, may be confounded and the genetic structure of the study population may be responsible for this effect. Simulation experiments show that levels of linkage disequilibrium (LD) and other parameters of the population...

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Detalles Bibliográficos
Autores principales: Yashin, Anatoliy I., Zhbannikov, Ilya, Arbeeva, Liubov, Arbeev, Konstantin G., Wu, Deqing, Akushevich, Igor, Yashkin, Arseniy, Kovtun, Mikhail, Kulminski, Alexander M., Stallard, Eric, Kulminskaya, Irina, Ukraintseva, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099244/
https://www.ncbi.nlm.nih.gov/pubmed/27877192
http://dx.doi.org/10.3389/fgene.2016.00188

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