The Roles of CD137 Signaling in Atherosclerosis

The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule a...

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Detalles Bibliográficos
Autores principales: Jung, In-Hyuk, Oh, Goo Taeg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Cardiology 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099328/
https://www.ncbi.nlm.nih.gov/pubmed/27826331
http://dx.doi.org/10.4070/kcj.2016.46.6.753
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author Jung, In-Hyuk
Oh, Goo Taeg
author_facet Jung, In-Hyuk
Oh, Goo Taeg
author_sort Jung, In-Hyuk
collection PubMed
description The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule and has been reported to be expressed in human atherosclerotic plaque lesions, and plays pivotal roles in mediating disease processes. In this review, we focus on and summarize recent advances in mouse studies on the involvement of CD137 signaling in the pathogenesis and plaque stability of atherosclerosis, thereby highlighting a valuable therapeutic target in atherosclerosis.
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spelling pubmed-50993282016-11-08 The Roles of CD137 Signaling in Atherosclerosis Jung, In-Hyuk Oh, Goo Taeg Korean Circ J Review Article The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule and has been reported to be expressed in human atherosclerotic plaque lesions, and plays pivotal roles in mediating disease processes. In this review, we focus on and summarize recent advances in mouse studies on the involvement of CD137 signaling in the pathogenesis and plaque stability of atherosclerosis, thereby highlighting a valuable therapeutic target in atherosclerosis. The Korean Society of Cardiology 2016-11 2016-10-20 /pmc/articles/PMC5099328/ /pubmed/27826331 http://dx.doi.org/10.4070/kcj.2016.46.6.753 Text en Copyright © 2016 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jung, In-Hyuk
Oh, Goo Taeg
The Roles of CD137 Signaling in Atherosclerosis
title The Roles of CD137 Signaling in Atherosclerosis
title_full The Roles of CD137 Signaling in Atherosclerosis
title_fullStr The Roles of CD137 Signaling in Atherosclerosis
title_full_unstemmed The Roles of CD137 Signaling in Atherosclerosis
title_short The Roles of CD137 Signaling in Atherosclerosis
title_sort roles of cd137 signaling in atherosclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099328/
https://www.ncbi.nlm.nih.gov/pubmed/27826331
http://dx.doi.org/10.4070/kcj.2016.46.6.753
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