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Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension

BACKGROUND AND OBJECTIVES: Non-dipper hypertension is frequently accompanied by endothelial dysfunction and activation. Previous studies suggested that endocan may be a novel endothelial dysfunction marker. This study aims to investigate the association between circadian blood pressure (BP) pattern...

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Autores principales: Çimen, Tolga, Bilgin, Murat, Akyel, Ahmet, Felekoğlu, Mehmet Ali, Nallbani, Ali, Özdemir, Şeyda, Erden, Gönül, Öztürk, Alpaslan, Doğan, Mehmet, Yeter, Ekrem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Cardiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099339/
https://www.ncbi.nlm.nih.gov/pubmed/27826342
http://dx.doi.org/10.4070/kcj.2016.46.6.827
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author Çimen, Tolga
Bilgin, Murat
Akyel, Ahmet
Felekoğlu, Mehmet Ali
Nallbani, Ali
Özdemir, Şeyda
Erden, Gönül
Öztürk, Alpaslan
Doğan, Mehmet
Yeter, Ekrem
author_facet Çimen, Tolga
Bilgin, Murat
Akyel, Ahmet
Felekoğlu, Mehmet Ali
Nallbani, Ali
Özdemir, Şeyda
Erden, Gönül
Öztürk, Alpaslan
Doğan, Mehmet
Yeter, Ekrem
author_sort Çimen, Tolga
collection PubMed
description BACKGROUND AND OBJECTIVES: Non-dipper hypertension is frequently accompanied by endothelial dysfunction and activation. Previous studies suggested that endocan may be a novel endothelial dysfunction marker. This study aims to investigate the association between circadian blood pressure (BP) pattern and plasma endocan levels together with high-sensitivity C-reactive protein (hsCRP) in patients with newly diagnosed untreated hypertension. SUBJECTS AND METHODS: Twenty-four hour ambulatory blood pressure monitoring was recorded in 35 dipper, 35 non-dipper hypertensives and 35 healthy controls. Endocan levels were measured by enzyme-linked immunosorbent assay. Serum levels of hsCRP were also recorded. RESULTS: Despite similar daytime and 24-hour average BP values between dippers and non-dippers, statistically significant high nocturnal BP was accompanied by a non-dipping pattern (Systolic BP: 132±9 vs. 147±11 mmHg; Distolic BP: 80±7 vs. 91±9 mmHg, respectively, p<0.001 for both). Non-dipper patients demonstrated higher endocan levels compared to dippers and normotensives (367 (193-844) pg/mL, 254 (182-512) pg/mL and 237 (141-314) pg/ml, respectively, p<0.001). HsCRP levels were significantly higher in non-dippers than the other groups (p=0.013). In a multivariate logistic regression analysis, endocan (p=0.021) and hsCRP (p=0.044) were independently associated with a non-dipping pattern. CONCLUSION: Elevated endocan levels were found in non-dipper groups. Endocan and hsCRP were found to be independently associated with a non-dipping pattern. We suggest that elevated levels of endocan in non-dipper hypertensive patients might be associated with a longer duration of exposure to high BP. These results point to the possible future role of endocan in selection of hypertensive patients at higher risk or target organ damage.
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spelling pubmed-50993392016-11-08 Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension Çimen, Tolga Bilgin, Murat Akyel, Ahmet Felekoğlu, Mehmet Ali Nallbani, Ali Özdemir, Şeyda Erden, Gönül Öztürk, Alpaslan Doğan, Mehmet Yeter, Ekrem Korean Circ J Original Article BACKGROUND AND OBJECTIVES: Non-dipper hypertension is frequently accompanied by endothelial dysfunction and activation. Previous studies suggested that endocan may be a novel endothelial dysfunction marker. This study aims to investigate the association between circadian blood pressure (BP) pattern and plasma endocan levels together with high-sensitivity C-reactive protein (hsCRP) in patients with newly diagnosed untreated hypertension. SUBJECTS AND METHODS: Twenty-four hour ambulatory blood pressure monitoring was recorded in 35 dipper, 35 non-dipper hypertensives and 35 healthy controls. Endocan levels were measured by enzyme-linked immunosorbent assay. Serum levels of hsCRP were also recorded. RESULTS: Despite similar daytime and 24-hour average BP values between dippers and non-dippers, statistically significant high nocturnal BP was accompanied by a non-dipping pattern (Systolic BP: 132±9 vs. 147±11 mmHg; Distolic BP: 80±7 vs. 91±9 mmHg, respectively, p<0.001 for both). Non-dipper patients demonstrated higher endocan levels compared to dippers and normotensives (367 (193-844) pg/mL, 254 (182-512) pg/mL and 237 (141-314) pg/ml, respectively, p<0.001). HsCRP levels were significantly higher in non-dippers than the other groups (p=0.013). In a multivariate logistic regression analysis, endocan (p=0.021) and hsCRP (p=0.044) were independently associated with a non-dipping pattern. CONCLUSION: Elevated endocan levels were found in non-dipper groups. Endocan and hsCRP were found to be independently associated with a non-dipping pattern. We suggest that elevated levels of endocan in non-dipper hypertensive patients might be associated with a longer duration of exposure to high BP. These results point to the possible future role of endocan in selection of hypertensive patients at higher risk or target organ damage. The Korean Society of Cardiology 2016-11 2016-11-01 /pmc/articles/PMC5099339/ /pubmed/27826342 http://dx.doi.org/10.4070/kcj.2016.46.6.827 Text en Copyright © 2016 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Çimen, Tolga
Bilgin, Murat
Akyel, Ahmet
Felekoğlu, Mehmet Ali
Nallbani, Ali
Özdemir, Şeyda
Erden, Gönül
Öztürk, Alpaslan
Doğan, Mehmet
Yeter, Ekrem
Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension
title Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension
title_full Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension
title_fullStr Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension
title_full_unstemmed Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension
title_short Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension
title_sort endocan and non-dipping circadian pattern in newly diagnosed essential hypertension
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099339/
https://www.ncbi.nlm.nih.gov/pubmed/27826342
http://dx.doi.org/10.4070/kcj.2016.46.6.827
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