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STAT4 gene polymorphism in patients after renal allograft transplantation

INTRODUCTION: STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been...

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Autores principales: Dąbrowska-Żamojcin, Ewa, Dziedziejko, Violetta, Safranow, Krzysztof, Domański, Leszek, Słuczanowska-Głabowska, Sylwia, Pawlik, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Society of Experimental and Clinical Immunology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099381/
https://www.ncbi.nlm.nih.gov/pubmed/27833442
http://dx.doi.org/10.5114/ceji.2016.63124
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author Dąbrowska-Żamojcin, Ewa
Dziedziejko, Violetta
Safranow, Krzysztof
Domański, Leszek
Słuczanowska-Głabowska, Sylwia
Pawlik, Andrzej
author_facet Dąbrowska-Żamojcin, Ewa
Dziedziejko, Violetta
Safranow, Krzysztof
Domański, Leszek
Słuczanowska-Głabowska, Sylwia
Pawlik, Andrzej
author_sort Dąbrowska-Żamojcin, Ewa
collection PubMed
description INTRODUCTION: STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, we examined whether this polymorphism is associated with the early and late functions of renal allografts. MATERIAL AND METHODS: A total of 270 recipients of first renal transplants were included in the study. Single nucleotide polymorphisms (SNPs) within the STAT4 gene were genotyped using TaqMan genotyping assays. RESULTS: There were no statistically significant associations between the STAT4 gene rs7574865 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction, post-transplant diabetes mellitus, or creatinine serum concentrations after transplantation. CONCLUSIONS: Our results suggest a lack of association between the STAT4 rs7574865 SNP and kidney allograft function in the Polish population.
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spelling pubmed-50993812016-11-10 STAT4 gene polymorphism in patients after renal allograft transplantation Dąbrowska-Żamojcin, Ewa Dziedziejko, Violetta Safranow, Krzysztof Domański, Leszek Słuczanowska-Głabowska, Sylwia Pawlik, Andrzej Cent Eur J Immunol Clinical Immunology INTRODUCTION: STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, we examined whether this polymorphism is associated with the early and late functions of renal allografts. MATERIAL AND METHODS: A total of 270 recipients of first renal transplants were included in the study. Single nucleotide polymorphisms (SNPs) within the STAT4 gene were genotyped using TaqMan genotyping assays. RESULTS: There were no statistically significant associations between the STAT4 gene rs7574865 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction, post-transplant diabetes mellitus, or creatinine serum concentrations after transplantation. CONCLUSIONS: Our results suggest a lack of association between the STAT4 rs7574865 SNP and kidney allograft function in the Polish population. Polish Society of Experimental and Clinical Immunology 2016-10-25 2016 /pmc/articles/PMC5099381/ /pubmed/27833442 http://dx.doi.org/10.5114/ceji.2016.63124 Text en Copyright: © 2016 Polish Society of Experimental and Clinical Immunology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Immunology
Dąbrowska-Żamojcin, Ewa
Dziedziejko, Violetta
Safranow, Krzysztof
Domański, Leszek
Słuczanowska-Głabowska, Sylwia
Pawlik, Andrzej
STAT4 gene polymorphism in patients after renal allograft transplantation
title STAT4 gene polymorphism in patients after renal allograft transplantation
title_full STAT4 gene polymorphism in patients after renal allograft transplantation
title_fullStr STAT4 gene polymorphism in patients after renal allograft transplantation
title_full_unstemmed STAT4 gene polymorphism in patients after renal allograft transplantation
title_short STAT4 gene polymorphism in patients after renal allograft transplantation
title_sort stat4 gene polymorphism in patients after renal allograft transplantation
topic Clinical Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099381/
https://www.ncbi.nlm.nih.gov/pubmed/27833442
http://dx.doi.org/10.5114/ceji.2016.63124
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