High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications

High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflam...

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Detalles Bibliográficos
Autores principales: Wu, Han, Chen, Zheng, Xie, Jun, Kang, Li-Na, Wang, Lian, Xu, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099456/
https://www.ncbi.nlm.nih.gov/pubmed/27847406
http://dx.doi.org/10.1155/2016/3896147
Descripción
Sumario:High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflammation, in addition to its role in progression of diabetes, also promotes initiation and development of diabetic complications. In this review, we focus on the role of HMGB-1 in diabetes-related complications and the therapeutic strategies targeting HMGB-1 in diabetic complications.

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