High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications

High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflam...

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Detalles Bibliográficos
Autores principales: Wu, Han, Chen, Zheng, Xie, Jun, Kang, Li-Na, Wang, Lian, Xu, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099456/
https://www.ncbi.nlm.nih.gov/pubmed/27847406
http://dx.doi.org/10.1155/2016/3896147
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author Wu, Han
Chen, Zheng
Xie, Jun
Kang, Li-Na
Wang, Lian
Xu, Biao
author_facet Wu, Han
Chen, Zheng
Xie, Jun
Kang, Li-Na
Wang, Lian
Xu, Biao
author_sort Wu, Han
collection PubMed
description High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflammation, in addition to its role in progression of diabetes, also promotes initiation and development of diabetic complications. In this review, we focus on the role of HMGB-1 in diabetes-related complications and the therapeutic strategies targeting HMGB-1 in diabetic complications.
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spelling pubmed-50994562016-11-15 High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications Wu, Han Chen, Zheng Xie, Jun Kang, Li-Na Wang, Lian Xu, Biao Mediators Inflamm Review Article High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflammation, in addition to its role in progression of diabetes, also promotes initiation and development of diabetic complications. In this review, we focus on the role of HMGB-1 in diabetes-related complications and the therapeutic strategies targeting HMGB-1 in diabetic complications. Hindawi Publishing Corporation 2016 2016-10-25 /pmc/articles/PMC5099456/ /pubmed/27847406 http://dx.doi.org/10.1155/2016/3896147 Text en Copyright © 2016 Han Wu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wu, Han
Chen, Zheng
Xie, Jun
Kang, Li-Na
Wang, Lian
Xu, Biao
High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications
title High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications
title_full High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications
title_fullStr High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications
title_full_unstemmed High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications
title_short High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications
title_sort high mobility group box-1: a missing link between diabetes and its complications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099456/
https://www.ncbi.nlm.nih.gov/pubmed/27847406
http://dx.doi.org/10.1155/2016/3896147
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