Autophagy Promoted the Degradation of Mutant ATXN3 in Neurally Differentiated Spinocerebellar Ataxia-3 Human Induced Pluripotent Stem Cells

Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autop...

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Detalles Bibliográficos
Autores principales: Ou, Zhanhui, Luo, Min, Niu, Xiaohua, Chen, Yuchang, Xie, Yingjun, He, Wenyin, Song, Bing, Xian, Yexing, Fan, Di, OuYang, Shuming, Sun, Xiaofang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099487/
https://www.ncbi.nlm.nih.gov/pubmed/27847820
http://dx.doi.org/10.1155/2016/6701793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099487/
https://www.ncbi.nlm.nih.gov/pubmed/27847820
http://dx.doi.org/10.1155/2016/6701793

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