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Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy
Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouraci...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099601/ https://www.ncbi.nlm.nih.gov/pubmed/27872837 http://dx.doi.org/10.5527/wjn.v5.i6.547 |
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author | Gadde, Shilpa Lee, Belinda Kidd, Laura Zhang, Rubin |
author_facet | Gadde, Shilpa Lee, Belinda Kidd, Laura Zhang, Rubin |
author_sort | Gadde, Shilpa |
collection | PubMed |
description | Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouracil, hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine and few other drugs. All previously reported cases of drug-associated ANCA glomerulonephritis were in native kidneys. Sofosbuvir is a new and effective drug for hepatitis C virus infection. Here, we report a case of ANCA vasculitis and RPGN following sofosbuvir administration in a kidney transplant recipient. It also represents the first case of drug-associated ANCA vasculitis in a transplanted kidney. Further drug monitoring is necessary to elucidate the degree of association and possible causal effect of sofosbuvir and perinuclear ANCA vasculitis. |
format | Online Article Text |
id | pubmed-5099601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-50996012016-11-21 Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy Gadde, Shilpa Lee, Belinda Kidd, Laura Zhang, Rubin World J Nephrol Case Report Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouracil, hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine and few other drugs. All previously reported cases of drug-associated ANCA glomerulonephritis were in native kidneys. Sofosbuvir is a new and effective drug for hepatitis C virus infection. Here, we report a case of ANCA vasculitis and RPGN following sofosbuvir administration in a kidney transplant recipient. It also represents the first case of drug-associated ANCA vasculitis in a transplanted kidney. Further drug monitoring is necessary to elucidate the degree of association and possible causal effect of sofosbuvir and perinuclear ANCA vasculitis. Baishideng Publishing Group Inc 2016-11-06 2016-11-06 /pmc/articles/PMC5099601/ /pubmed/27872837 http://dx.doi.org/10.5527/wjn.v5.i6.547 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Gadde, Shilpa Lee, Belinda Kidd, Laura Zhang, Rubin Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy |
title | Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy |
title_full | Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy |
title_fullStr | Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy |
title_full_unstemmed | Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy |
title_short | Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy |
title_sort | antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099601/ https://www.ncbi.nlm.nih.gov/pubmed/27872837 http://dx.doi.org/10.5527/wjn.v5.i6.547 |
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