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Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy

Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouraci...

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Autores principales: Gadde, Shilpa, Lee, Belinda, Kidd, Laura, Zhang, Rubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099601/
https://www.ncbi.nlm.nih.gov/pubmed/27872837
http://dx.doi.org/10.5527/wjn.v5.i6.547
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author Gadde, Shilpa
Lee, Belinda
Kidd, Laura
Zhang, Rubin
author_facet Gadde, Shilpa
Lee, Belinda
Kidd, Laura
Zhang, Rubin
author_sort Gadde, Shilpa
collection PubMed
description Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouracil, hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine and few other drugs. All previously reported cases of drug-associated ANCA glomerulonephritis were in native kidneys. Sofosbuvir is a new and effective drug for hepatitis C virus infection. Here, we report a case of ANCA vasculitis and RPGN following sofosbuvir administration in a kidney transplant recipient. It also represents the first case of drug-associated ANCA vasculitis in a transplanted kidney. Further drug monitoring is necessary to elucidate the degree of association and possible causal effect of sofosbuvir and perinuclear ANCA vasculitis.
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spelling pubmed-50996012016-11-21 Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy Gadde, Shilpa Lee, Belinda Kidd, Laura Zhang, Rubin World J Nephrol Case Report Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouracil, hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine and few other drugs. All previously reported cases of drug-associated ANCA glomerulonephritis were in native kidneys. Sofosbuvir is a new and effective drug for hepatitis C virus infection. Here, we report a case of ANCA vasculitis and RPGN following sofosbuvir administration in a kidney transplant recipient. It also represents the first case of drug-associated ANCA vasculitis in a transplanted kidney. Further drug monitoring is necessary to elucidate the degree of association and possible causal effect of sofosbuvir and perinuclear ANCA vasculitis. Baishideng Publishing Group Inc 2016-11-06 2016-11-06 /pmc/articles/PMC5099601/ /pubmed/27872837 http://dx.doi.org/10.5527/wjn.v5.i6.547 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Gadde, Shilpa
Lee, Belinda
Kidd, Laura
Zhang, Rubin
Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy
title Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy
title_full Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy
title_fullStr Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy
title_full_unstemmed Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy
title_short Antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy
title_sort antineutrophil cytoplasmic antibodies crescentic allograft glomerulonephritis after sofosbuvir therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099601/
https://www.ncbi.nlm.nih.gov/pubmed/27872837
http://dx.doi.org/10.5527/wjn.v5.i6.547
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