B7-H1 antibodies lose antitumor activity due to activation of p38 MAPK that leads to apoptosis of tumor-reactive CD8(+) T cells

B7-H1 (aka PD-L1) blocking antibodies have been used in treatment of human cancers through blocking B7-H1 expressed by tumor cells; however, their impact on B7-H1 expressing tumor-reactive CD8(+) T cells is still unknown. Here, we report that tumor-reactive CD8(+) T cells expressing B7-H1 are functi...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Wu, Xiaosheng, Cao, Siyu, Harrington, Susan M., Yin, Peng, Mansfield, Aaron S., Dong, Haidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099859/
https://www.ncbi.nlm.nih.gov/pubmed/27824138
http://dx.doi.org/10.1038/srep36722

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