Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE(−/−) mice: implications for Alzheimer’s disease

Alzheimer’s disease (AD) patients suffer sleep disorders and circadian rhythm disturbances (CRDs). The underlying mechanisms are incompletely understood, and treatments are lacking. In this study, we characterized the locomotor activity, clock gene expression, morphological degeneration and energy m...

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Detalles Bibliográficos
Autores principales: Zhou, Lan, Gao, Qian, Nie, Meng, Gu, Jing-Li, Hao, Wei, Wang, Lin, Cao, Ji-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099891/
https://www.ncbi.nlm.nih.gov/pubmed/27824104
http://dx.doi.org/10.1038/srep36335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099891/
https://www.ncbi.nlm.nih.gov/pubmed/27824104
http://dx.doi.org/10.1038/srep36335

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