Cargando…

The effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report

Peripheral circulation is severely compromised in the advanced stages of peripheral arterial disease. Recently, it was shown that the application of −40 mmHg intermittent negative pressure (INP) to the lower leg and foot enhances macro‐ and microcirculation in healthy volunteers. In this case report...

Descripción completa

Detalles Bibliográficos
Autores principales: Sundby, Øyvind H., Høiseth, Lars Ø., Mathiesen, Iacob, Jørgensen, Jørgen J., Sundhagen, Jon O., Hisdal, Jonny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099962/
https://www.ncbi.nlm.nih.gov/pubmed/27798353
http://dx.doi.org/10.14814/phy2.12998
_version_ 1782466039980752896
author Sundby, Øyvind H.
Høiseth, Lars Ø.
Mathiesen, Iacob
Jørgensen, Jørgen J.
Sundhagen, Jon O.
Hisdal, Jonny
author_facet Sundby, Øyvind H.
Høiseth, Lars Ø.
Mathiesen, Iacob
Jørgensen, Jørgen J.
Sundhagen, Jon O.
Hisdal, Jonny
author_sort Sundby, Øyvind H.
collection PubMed
description Peripheral circulation is severely compromised in the advanced stages of peripheral arterial disease. Recently, it was shown that the application of −40 mmHg intermittent negative pressure (INP) to the lower leg and foot enhances macro‐ and microcirculation in healthy volunteers. In this case report, we describe the effects of INP treatment on four patients with lower limb ischemia and hard‐to‐heal leg and foot ulcers. We hypothesized that INP therapy may have beneficial hemodynamic and clinical effects in the patients. Four patients (age range: 61–79 years) with hard‐to‐heal leg and foot ulcers (6–24 months) and ankle‐brachial pressure indices of ≤0.60 on the affected side were included. They were treated with an 8‐week intervention period of −40 mmHg INP (10 sec negative pressure and 7 sec atmospheric pressure) on the lower limbs. A custom‐made vacuum chamber was used to apply INP to the affected lower leg and foot for 2 h per day. After 8 weeks of INP therapy, one ulcer healed completely, while the other three ulcers were almost completely healed. These cases suggest that INP may facilitate wound healing. The theoretical foundation is that INP assists wound healing by improving blood flow to the small blood vessels in the affected limb, increasing the flow of oxygen and nutrients to the cells.
format Online
Article
Text
id pubmed-5099962
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-50999622016-11-14 The effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report Sundby, Øyvind H. Høiseth, Lars Ø. Mathiesen, Iacob Jørgensen, Jørgen J. Sundhagen, Jon O. Hisdal, Jonny Physiol Rep Case Reports Peripheral circulation is severely compromised in the advanced stages of peripheral arterial disease. Recently, it was shown that the application of −40 mmHg intermittent negative pressure (INP) to the lower leg and foot enhances macro‐ and microcirculation in healthy volunteers. In this case report, we describe the effects of INP treatment on four patients with lower limb ischemia and hard‐to‐heal leg and foot ulcers. We hypothesized that INP therapy may have beneficial hemodynamic and clinical effects in the patients. Four patients (age range: 61–79 years) with hard‐to‐heal leg and foot ulcers (6–24 months) and ankle‐brachial pressure indices of ≤0.60 on the affected side were included. They were treated with an 8‐week intervention period of −40 mmHg INP (10 sec negative pressure and 7 sec atmospheric pressure) on the lower limbs. A custom‐made vacuum chamber was used to apply INP to the affected lower leg and foot for 2 h per day. After 8 weeks of INP therapy, one ulcer healed completely, while the other three ulcers were almost completely healed. These cases suggest that INP may facilitate wound healing. The theoretical foundation is that INP assists wound healing by improving blood flow to the small blood vessels in the affected limb, increasing the flow of oxygen and nutrients to the cells. John Wiley and Sons Inc. 2016-10-26 /pmc/articles/PMC5099962/ /pubmed/27798353 http://dx.doi.org/10.14814/phy2.12998 Text en © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Sundby, Øyvind H.
Høiseth, Lars Ø.
Mathiesen, Iacob
Jørgensen, Jørgen J.
Sundhagen, Jon O.
Hisdal, Jonny
The effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report
title The effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report
title_full The effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report
title_fullStr The effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report
title_full_unstemmed The effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report
title_short The effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report
title_sort effects of intermittent negative pressure on the lower extremities' peripheral circulation and wound healing in four patients with lower limb ischemia and hard‐to‐heal leg ulcers: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099962/
https://www.ncbi.nlm.nih.gov/pubmed/27798353
http://dx.doi.org/10.14814/phy2.12998
work_keys_str_mv AT sundbyøyvindh theeffectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT høisethlarsø theeffectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT mathieseniacob theeffectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT jørgensenjørgenj theeffectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT sundhagenjono theeffectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT hisdaljonny theeffectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT sundbyøyvindh effectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT høisethlarsø effectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT mathieseniacob effectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT jørgensenjørgenj effectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT sundhagenjono effectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport
AT hisdaljonny effectsofintermittentnegativepressureonthelowerextremitiesperipheralcirculationandwoundhealinginfourpatientswithlowerlimbischemiaandhardtoheallegulcersacasereport