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Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice

STUDY QUESTION: Does the Irinotecan metabolite 7-ethyl-10-hydroxycamptothecan (SN38) damage the gonads of male and female prepubertal mice? SUMMARY ANSWER: The Irinotecan metabolite SN38 reduces germ cell numbers within the seminiferous tubules of mouse testes at concentrations that are relevant to...

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Detalles Bibliográficos
Autores principales:	Lopes, Federica, Smith, Rowena, Nash, Sophie, Mitchell, Rod T., Spears, Norah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099998/ https://www.ncbi.nlm.nih.gov/pubmed/27470502 http://dx.doi.org/10.1093/molehr/gaw051

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