Intracellular TRPA1 mediates Ca(2+) release from lysosomes in dorsal root ganglion neurons

Transient receptor potential A1 (TRPA1) is a nonselective cation channel implicated in thermosensation and inflammatory pain. In this study, we show that TRPA1 (activated by allyl isothiocyanate, acrolein, and 4-hydroxynonenal) elevates the intracellular Ca(2+) concentration ([Ca(2+)](i)) in dorsal...

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Detalles Bibliográficos
Autores principales: Shang, Shujiang, Zhu, Feipeng, Liu, Bin, Chai, Zuying, Wu, Qihui, Hu, Meiqin, Wang, Yuan, Huang, Rong, Zhang, Xiaoyu, Wu, Xi, Sun, Lei, Wang, Yeshi, Wang, Li, Xu, Huadong, Teng, Sasa, Liu, Bing, Zheng, Lianghong, Zhang, Chen, Zhang, Fukang, Feng, Xinghua, Zhu, Desheng, Wang, Changhe, Liu, Tao, Zhu, Michael X., Zhou, Zhuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100290/
https://www.ncbi.nlm.nih.gov/pubmed/27799370
http://dx.doi.org/10.1083/jcb.201603081

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