Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes

An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have been involved in C9ORF72 related ALS/FTLD. The gf me...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Hao, Limin, Saur, Taixiang, Joyal, Katelyn, Zhao, Ying, Zhai, Desheng, Li, Jie, Pribadi, Mochtar, Coppola, Giovanni, Cohen, Bruce M., Buttner, Edgar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100550/
https://www.ncbi.nlm.nih.gov/pubmed/27877110
http://dx.doi.org/10.3389/fnmol.2016.00113

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