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Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication

In eukaryotic DNA replication initiation, hexameric MCM (mini-chromosome maintenance) unwinds the template double-stranded DNA to form the replication fork. MCM is activated by two proteins, Cdc45 and GINS, which constitute the ‘CMG’ unwindosome complex together with the MCM core. The archaeal DNA r...

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Detalles Bibliográficos
Autores principales:	Oyama, Takuji, Ishino, Sonoko, Shirai, Tsuyoshi, Yamagami, Takeshi, Nagata, Mariko, Ogino, Hiromi, Kusunoki, Masami, Ishino, Yoshizumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100581/ https://www.ncbi.nlm.nih.gov/pubmed/27599844 http://dx.doi.org/10.1093/nar/gkw789

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