Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant

We explore the possibility of re-engineering mitochondrial genes and expressing them from the nucleus as an approach to rescue defects arising from mitochondrial DNA mutations. We have used a patient cybrid cell line with a single point mutation in the overlap region of the ATP8 and ATP6 genes of th...

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Detalles Bibliográficos
Autores principales: Boominathan, Amutha, Vanhoozer, Shon, Basisty, Nathan, Powers, Kathleen, Crampton, Alexandra L., Wang, Xiaobin, Friedricks, Natalie, Schilling, Birgit, Brand, Martin D., O'Connor, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100594/
https://www.ncbi.nlm.nih.gov/pubmed/27596602
http://dx.doi.org/10.1093/nar/gkw756

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