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Translesion synthesis of O(4)-alkylthymidine lesions in human cells

Environmental exposure, endogenous metabolism and cancer chemotherapy can give rise to alkylation of DNA, and the resulting alkylated thymidine (alkyldT) lesions were found to be poorly repaired and persistent in mammalian tissues. Unrepaired DNA lesions may compromise genomic integrity by inhibitin...

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Detalles Bibliográficos
Autores principales:	Wu, Jun, Li, Lin, Wang, Pengcheng, You, Changjun, Williams, Nicole L., Wang, Yinsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100597/ https://www.ncbi.nlm.nih.gov/pubmed/27466394 http://dx.doi.org/10.1093/nar/gkw662

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