Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function

LincRNA-p21 is a long intergenic non-coding RNA (lincRNA) involved in the p53-mediated stress response. We sequenced the human lincRNA-p21 (hLincRNA-p21) and found that it has a single exon that includes inverted repeat Alu elements (IRAlus). Sense and antisense Alu elements fold independently of on...

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Detalles Bibliográficos
Autores principales: Chillón, Isabel, Pyle, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100600/
https://www.ncbi.nlm.nih.gov/pubmed/27378782
http://dx.doi.org/10.1093/nar/gkw599
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author Chillón, Isabel
Pyle, Anna M.
author_facet Chillón, Isabel
Pyle, Anna M.
author_sort Chillón, Isabel
collection PubMed
description LincRNA-p21 is a long intergenic non-coding RNA (lincRNA) involved in the p53-mediated stress response. We sequenced the human lincRNA-p21 (hLincRNA-p21) and found that it has a single exon that includes inverted repeat Alu elements (IRAlus). Sense and antisense Alu elements fold independently of one another into a secondary structure that is conserved in lincRNA-p21 among primates. Moreover, the structures formed by IRAlus are involved in the localization of hLincRNA-p21 in the nucleus, where hLincRNA-p21 colocalizes with paraspeckles. Our results underscore the importance of IRAlus structures for the function of hLincRNA-p21 during the stress response.
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spelling pubmed-51006002016-11-10 Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function Chillón, Isabel Pyle, Anna M. Nucleic Acids Res RNA LincRNA-p21 is a long intergenic non-coding RNA (lincRNA) involved in the p53-mediated stress response. We sequenced the human lincRNA-p21 (hLincRNA-p21) and found that it has a single exon that includes inverted repeat Alu elements (IRAlus). Sense and antisense Alu elements fold independently of one another into a secondary structure that is conserved in lincRNA-p21 among primates. Moreover, the structures formed by IRAlus are involved in the localization of hLincRNA-p21 in the nucleus, where hLincRNA-p21 colocalizes with paraspeckles. Our results underscore the importance of IRAlus structures for the function of hLincRNA-p21 during the stress response. Oxford University Press 2016-11-02 2016-07-04 /pmc/articles/PMC5100600/ /pubmed/27378782 http://dx.doi.org/10.1093/nar/gkw599 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle RNA
Chillón, Isabel
Pyle, Anna M.
Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function
title Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function
title_full Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function
title_fullStr Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function
title_full_unstemmed Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function
title_short Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function
title_sort inverted repeat alu elements in the human lincrna-p21 adopt a conserved secondary structure that regulates rna function
topic RNA
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100600/
https://www.ncbi.nlm.nih.gov/pubmed/27378782
http://dx.doi.org/10.1093/nar/gkw599
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