Cargando…

From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter

Retrieval of congeneric and consistent SAR data sets for protein targets of interest is still a laborious task to do if no appropriate in-house data set is available. However, combining integrated open data sources (such as the Open PHACTS Discovery Platform) with workflow tools now offers the possi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zdrazil, Barbara, Hellsberg, Eva, Viereck, Michael, Ecker, Gerhard F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100691/ https://www.ncbi.nlm.nih.gov/pubmed/27891211 http://dx.doi.org/10.1039/c6md00207b

Ejemplares similares

A structural model of the human serotonin transporter in an outward-occluded state
por: Hellsberg, Eva, et al.
Publicado: (2019)

Mutations in the amino-terminus impair amphetamine-induced efflux by inducing inward-facing conformations of the serotonin transporter
por: Sucic, Sonja, et al.
Publicado: (2009)

Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling
por: Seddik, Amir, et al.
Publicado: (2013)

Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking Dopamine and/or Serotonin Transporters
por: Hagino, Y, et al.
Publicado: (2011)

Taking Open Innovation to the Molecular Level - Strengths and Limitations
por: Zdrazil, Barbara, et al.
Publicado: (2012)

Empowering pharmacoinformatics by linked life science data
por: Goldmann, Daria, et al.
Publicado: (2016)

The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters
por: Nam, Su Bong, et al.
Publicado: (2018)

Serotonin/Dopamine Interactions in a Hyperactive Mouse: Reduced Serotonin Receptor 1B Activity Reverses Effects of Dopamine Transporter Knockout
por: Hall, Frank Scott, et al.
Publicado: (2014)

How Open Data Shapes In Silico Transporter Modeling
por: Montanari, Floriane, et al.
Publicado: (2017)

Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram
por: Kumar, Vivek, et al.
Publicado: (2015)

The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters
por: Bulling, Simon, et al.
Publicado: (2012)

Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter
por: Traktirov, Dmitrii S., et al.
Publicado: (2023)

Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning
por: Montanari, Floriane, et al.
Publicado: (2016)

Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters
por: González-Gutiérrez, Juan Pablo, et al.
Publicado: (2019)

Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters
por: Steinkellner, Thomas, et al.
Publicado: (2012)

Modelling brain dopamine-serotonin vesicular transport disease in Caenorhabditis elegans
por: Young, Alexander T., et al.
Publicado: (2018)

A decoupler-free simple paper microchip capillary electrophoresis device for simultaneous detection of dopamine, epinephrine and serotonin
por: Roychoudhury, Appan, et al.
Publicado: (2020)

Bile Acids Gate Dopamine Transporter Mediated Currents
por: Romanazzi, Tiziana, et al.
Publicado: (2021)

Insights into binding events of GABA- and Tiagabine- analogues in the Gamma-Aminobutyric Acid Transporter 1 by means of Molecular Modelling
por: Zdrazil, Barbara, et al.
Publicado: (2012)

A Binding Mode Hypothesis of Tiagabine Confirms Liothyronine Effect on γ-Aminobutyric Acid Transporter 1 (GAT1)
por: Jurik, Andreas, et al.
Publicado: (2015)

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters
por: Bhat, Shreyas, et al.
Publicado: (2020)

Integrative Data Mining, Scaffold Analysis, and Sequential Binary Classification Models for Exploring Ligand Profiles of Hepatic Organic Anion Transporting Polypeptides
por: Türková, Alžběta, et al.
Publicado: (2018)

Selective serotonin reuptake inhibitor-induced cell death: in search of a mechanism
por: Glöckel, Christina, et al.
Publicado: (2010)

A study to understand the pattern of hyponatremia in patients using selective serotonin reuptake inhibitors and serotonin dopamine antagonists
por: Tomar, Love Kumar, et al.
Publicado: (2021)

CENTRAL DOPAMINE AND SEROTONIN TURNOVER IN SCHIZOPHRENIA
por: Pandey, R.S., et al.
Publicado: (1987)

Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy
por: Hjorth, Olof, et al.
Publicado: (2022)

The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter
por: Sarker, Subhodeep, et al.
Publicado: (2010)

Classification of High-Activity Tiagabine Analogs by Binary QSAR Modeling
por: Jurik, Andreas, et al.
Publicado: (2013)

APRESS: apical regulatory super system, serotonin, and dopamine interaction
por: Hinz, Marty, et al.
Publicado: (2011)

DOPAMINE AND SEROTONIN TRANSPORTER AVAILABILITY DURING ACUTE ALCOHOL WITHDRAWAL: EFFECTS OF COMORBID TOBACCO SMOKING
por: Cosgrove, Kelly P., et al.
Publicado: (2009)

Serotonin transporter gene polymorphism and psychiatric disorders: Is there a link?
por: Margoob, Mushtaq A., et al.
Publicado: (2011)

Mouse model of the human serotonin transporter-linked polymorphic region
por: Piszczek, Lukasz, et al.
Publicado: (2019)

Vienna LiverTox Workspace—A Set of Machine Learning Models for Prediction of Interactions Profiles of Small Molecules With Transporters Relevant for Regulatory Agencies
por: Montanari, Floriane, et al.
Publicado: (2020)

Formation of Monolithic Ion-Selective Transport Media Based on “Click” Cross-Linked Hyperbranched Polyglycerol
por: Abrahamsson, Tobias, et al.
Publicado: (2019)

Dopamine Receptor Ligand Selectivity—An In Silico/In Vitro Insight
por: Zell, Lukas, et al.
Publicado: (2023)

Dopamine Modulates Serotonin Innervation in the Drosophila Brain
por: Niens, Janna, et al.
Publicado: (2017)

Are dopamine and serotonin involved in COVID-19 pathophysiology?
por: Attademo, L., et al.
Publicado: (2021)

A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance
por: Huang, Jiahui, et al.
Publicado: (2023)

Pairwise structural comparison of tiagabine analogs gives new insights into their protein binding modes
por: Zdrazil, Barbara, et al.
Publicado: (2013)

Biomedical data analyses facilitated by open cheminformatics workflows
por: Nittinger, Eva, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9d8rc6qpigcvkj1gcslar23dc3