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Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT)

BACKGROUND AND PURPOSE: Intensity modulated radiotherapy requires all target areas to be treated by a single radiotherapy plan. In anal cancer, the pelvic nodes, inguinal nodes and primary tumour represent three different targets. We aim to calculate target-specific motion in anal cancer radiotherap...

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Autores principales: Durrant, Lisa, Robinson, Maxwell, Hawkins, Maria A., Van den Heuvel, Frank, Muirhead, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100804/
https://www.ncbi.nlm.nih.gov/pubmed/27576432
http://dx.doi.org/10.1016/j.radonc.2016.08.011
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author Durrant, Lisa
Robinson, Maxwell
Hawkins, Maria A.
Van den Heuvel, Frank
Muirhead, Rebecca
author_facet Durrant, Lisa
Robinson, Maxwell
Hawkins, Maria A.
Van den Heuvel, Frank
Muirhead, Rebecca
author_sort Durrant, Lisa
collection PubMed
description BACKGROUND AND PURPOSE: Intensity modulated radiotherapy requires all target areas to be treated by a single radiotherapy plan. In anal cancer, the pelvic nodes, inguinal nodes and primary tumour represent three different targets. We aim to calculate target-specific motion in anal cancer radiotherapy, when delivered using a single pelvic online auto-match. MATERIALS AND METHODS: Twenty consecutive patients treated using IMRT at a single institution were studied. CBCTs were retrospectively re-matched around the inguinal nodes and primary tumour. Match values were recorded relative to origin, defined as pelvic CBCT auto-match. Systematic and random errors were quantified to determine target-specific motion and suggested margins calculated using van Herk formulae. RESULTS: The suggested margins to cover the independent motion of the inguinal and anal targets for LR, CC and AP set up around the inguinal nodes were 1.5 mm, 2.7 mm and 2.8 mm; and the primary tumour were, 4.6 mm, 8.9 mm and 5.2 mm respectively. CONCLUSIONS: Target-specific set up will likely result in reduced treatment volumes and as such reduced toxicity. This is the first time a relationship has been described between pelvic bones, inguinal nodes and primary tumour. The PLATO study will prospectively assess the toxicity and outcomes of this target-specific margins strategy.
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spelling pubmed-51008042016-11-14 Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT) Durrant, Lisa Robinson, Maxwell Hawkins, Maria A. Van den Heuvel, Frank Muirhead, Rebecca Radiother Oncol Anal cancer IMRT BACKGROUND AND PURPOSE: Intensity modulated radiotherapy requires all target areas to be treated by a single radiotherapy plan. In anal cancer, the pelvic nodes, inguinal nodes and primary tumour represent three different targets. We aim to calculate target-specific motion in anal cancer radiotherapy, when delivered using a single pelvic online auto-match. MATERIALS AND METHODS: Twenty consecutive patients treated using IMRT at a single institution were studied. CBCTs were retrospectively re-matched around the inguinal nodes and primary tumour. Match values were recorded relative to origin, defined as pelvic CBCT auto-match. Systematic and random errors were quantified to determine target-specific motion and suggested margins calculated using van Herk formulae. RESULTS: The suggested margins to cover the independent motion of the inguinal and anal targets for LR, CC and AP set up around the inguinal nodes were 1.5 mm, 2.7 mm and 2.8 mm; and the primary tumour were, 4.6 mm, 8.9 mm and 5.2 mm respectively. CONCLUSIONS: Target-specific set up will likely result in reduced treatment volumes and as such reduced toxicity. This is the first time a relationship has been described between pelvic bones, inguinal nodes and primary tumour. The PLATO study will prospectively assess the toxicity and outcomes of this target-specific margins strategy. Elsevier Scientific Publishers 2016-10 /pmc/articles/PMC5100804/ /pubmed/27576432 http://dx.doi.org/10.1016/j.radonc.2016.08.011 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Anal cancer IMRT
Durrant, Lisa
Robinson, Maxwell
Hawkins, Maria A.
Van den Heuvel, Frank
Muirhead, Rebecca
Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT)
title Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT)
title_full Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT)
title_fullStr Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT)
title_full_unstemmed Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT)
title_short Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT)
title_sort quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (imrt)
topic Anal cancer IMRT
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100804/
https://www.ncbi.nlm.nih.gov/pubmed/27576432
http://dx.doi.org/10.1016/j.radonc.2016.08.011
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