Bifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ

Misfolding, abnormal accumulation, and secretion of α-Synuclein (α-Syn) are closely associated with synucleinopathies, including Parkinson’s disease (PD). VH14 is a human single domain intrabody selected against the non-amyloid component (NAC) hydrophobic interaction region of α-Syn, which is critic...

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Detalles Bibliográficos
Autores principales: Butler, David C., Joshi, Shubhada N., Genst, Erwin De, Baghel, Ankit S., Dobson, Christopher M., Messer, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100967/
https://www.ncbi.nlm.nih.gov/pubmed/27824888
http://dx.doi.org/10.1371/journal.pone.0165964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100967/
https://www.ncbi.nlm.nih.gov/pubmed/27824888
http://dx.doi.org/10.1371/journal.pone.0165964

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