Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

Expression changes of competing endogenous RNAs (ceRNAs) have been proposed to influence microRNA (miRNA) activity and thereby regulate other transcripts containing miRNA-binding sites. Here, we find that although miRNA levels define the extent of repression, they have little effect on the magnitude...

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Detalles Bibliográficos
Autores principales: Denzler, Rémy, McGeary, Sean E., Title, Alexandra C., Agarwal, Vikram, Bartel, David P., Stoffel, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101187/
https://www.ncbi.nlm.nih.gov/pubmed/27871486
http://dx.doi.org/10.1016/j.molcel.2016.09.027

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