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Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men
CONTEXT: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic–pituitary–gonadal (HPG) axis with familial longevity has not yet been investigated. OBJECTIVE: To study 24-h hormone concentration profiles of the HPG axis in men enriched for familial long...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101217/ https://www.ncbi.nlm.nih.gov/pubmed/27881971 http://dx.doi.org/10.3389/fendo.2016.00143 |
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author | van der Spoel, Evie Roelfsema, Ferdinand Jansen, Steffy W. Akintola, Abimbola A. Ballieux, Bart E. Cobbaert, Christa M. Blauw, Gerard J. Slagboom, P. Eline Westendorp, Rudi G. J. Pijl, Hanno van Heemst, Diana |
author_facet | van der Spoel, Evie Roelfsema, Ferdinand Jansen, Steffy W. Akintola, Abimbola A. Ballieux, Bart E. Cobbaert, Christa M. Blauw, Gerard J. Slagboom, P. Eline Westendorp, Rudi G. J. Pijl, Hanno van Heemst, Diana |
author_sort | van der Spoel, Evie |
collection | PubMed |
description | CONTEXT: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic–pituitary–gonadal (HPG) axis with familial longevity has not yet been investigated. OBJECTIVE: To study 24-h hormone concentration profiles of the HPG axis in men enriched for familial longevity and controls. DESIGN: We frequently sampled blood over 24 h in 10 healthy middle-aged male offspring of nonagenarian participants from the Leiden Longevity Study together with 10 male age-matched controls. Individual 24-h luteinizing hormone (LH) and testosterone concentration profiles were analyzed by deconvolution analyses to estimate secretion parameters. Furthermore, the temporal relationship between LH and testosterone was assessed by cross-correlation analysis. We used (cross-)approximate entropy to quantify the strength of feedback and/or feedforward control of LH and testosterone secretion. RESULTS: Mean [95% confidence interval (CI)] total LH secretion of the offspring was 212 (156–268) U/L/24 h, which did not differ significantly (p = 0.51) from the total LH secretion of controls [186 (130–242) U/L/24 h]. Likewise, mean (95% CI) total testosterone secretion of the offspring [806 (671–941) nmol/L/24 h] and controls [811 (676–947) nmol/L/24 h] were similar (p = 0.95). Other parameters of LH and testosterone secretion were also not significantly different between offspring and controls. The temporal relationship between LH and testosterone and the strength of feedforward/feedback regulation within the HPG axis were similar between offspring of long-lived families and controls. CONCLUSION: This relatively small study suggests that in healthy male middle-aged participants, familial longevity is not associated with major differences in the HPG axis. Selection on both fertility and health may in part explain the results. |
format | Online Article Text |
id | pubmed-5101217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51012172016-11-23 Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men van der Spoel, Evie Roelfsema, Ferdinand Jansen, Steffy W. Akintola, Abimbola A. Ballieux, Bart E. Cobbaert, Christa M. Blauw, Gerard J. Slagboom, P. Eline Westendorp, Rudi G. J. Pijl, Hanno van Heemst, Diana Front Endocrinol (Lausanne) Endocrinology CONTEXT: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic–pituitary–gonadal (HPG) axis with familial longevity has not yet been investigated. OBJECTIVE: To study 24-h hormone concentration profiles of the HPG axis in men enriched for familial longevity and controls. DESIGN: We frequently sampled blood over 24 h in 10 healthy middle-aged male offspring of nonagenarian participants from the Leiden Longevity Study together with 10 male age-matched controls. Individual 24-h luteinizing hormone (LH) and testosterone concentration profiles were analyzed by deconvolution analyses to estimate secretion parameters. Furthermore, the temporal relationship between LH and testosterone was assessed by cross-correlation analysis. We used (cross-)approximate entropy to quantify the strength of feedback and/or feedforward control of LH and testosterone secretion. RESULTS: Mean [95% confidence interval (CI)] total LH secretion of the offspring was 212 (156–268) U/L/24 h, which did not differ significantly (p = 0.51) from the total LH secretion of controls [186 (130–242) U/L/24 h]. Likewise, mean (95% CI) total testosterone secretion of the offspring [806 (671–941) nmol/L/24 h] and controls [811 (676–947) nmol/L/24 h] were similar (p = 0.95). Other parameters of LH and testosterone secretion were also not significantly different between offspring and controls. The temporal relationship between LH and testosterone and the strength of feedforward/feedback regulation within the HPG axis were similar between offspring of long-lived families and controls. CONCLUSION: This relatively small study suggests that in healthy male middle-aged participants, familial longevity is not associated with major differences in the HPG axis. Selection on both fertility and health may in part explain the results. Frontiers Media S.A. 2016-11-09 /pmc/articles/PMC5101217/ /pubmed/27881971 http://dx.doi.org/10.3389/fendo.2016.00143 Text en Copyright © 2016 van der Spoel, Roelfsema, Jansen, Akintola, Ballieux, Cobbaert, Blauw, Slagboom, Westendorp, Pijl and van Heemst. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology van der Spoel, Evie Roelfsema, Ferdinand Jansen, Steffy W. Akintola, Abimbola A. Ballieux, Bart E. Cobbaert, Christa M. Blauw, Gerard J. Slagboom, P. Eline Westendorp, Rudi G. J. Pijl, Hanno van Heemst, Diana Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men |
title | Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men |
title_full | Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men |
title_fullStr | Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men |
title_full_unstemmed | Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men |
title_short | Familial Longevity Is Not Associated with Major Differences in the Hypothalamic–Pituitary–Gonadal Axis in Healthy Middle-Aged Men |
title_sort | familial longevity is not associated with major differences in the hypothalamic–pituitary–gonadal axis in healthy middle-aged men |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101217/ https://www.ncbi.nlm.nih.gov/pubmed/27881971 http://dx.doi.org/10.3389/fendo.2016.00143 |
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