Cargando…

Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases

OBJECTIVE: The safety of the simultaneous resection of synchronous colorectal cancer liver metastases (SCRLM) is still being debated. However, this simultaneous operative approach is more commonly adopted at present than in the past. Therefore, we compared simultaneous hepatic resection with delayed...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yuan, Bi, Xinyu, Zhao, Jianjun, Huang, Zhen, Zhou, Jianguo, Li, Zhiyu, Zhang, Yefan, Zhao, Hong, Cai, Jianqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101227/
https://www.ncbi.nlm.nih.gov/pubmed/27877012
http://dx.doi.org/10.21147/j.issn.1000-9604.2016.05.08
_version_ 1782466248191246336
author Li, Yuan
Bi, Xinyu
Zhao, Jianjun
Huang, Zhen
Zhou, Jianguo
Li, Zhiyu
Zhang, Yefan
Zhao, Hong
Cai, Jianqiang
author_facet Li, Yuan
Bi, Xinyu
Zhao, Jianjun
Huang, Zhen
Zhou, Jianguo
Li, Zhiyu
Zhang, Yefan
Zhao, Hong
Cai, Jianqiang
author_sort Li, Yuan
collection PubMed
description OBJECTIVE: The safety of the simultaneous resection of synchronous colorectal cancer liver metastases (SCRLM) is still being debated. However, this simultaneous operative approach is more commonly adopted at present than in the past. Therefore, we compared simultaneous hepatic resection with delayed hepatic resection in this study. METHODS: All patients with SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included in our study. Short-term and long-term outcomes were compared in patients who underwent simultaneous colorectal and hepatic resection and those treated by delayed hepatectomy. RESULTS: Among the 73 patients diagnosed with SCRLM, simultaneous colorectal and hepatic resection was performed in 60 patients (82.2%), while delayed hepatic resection was performed in 13 patients (17.8%). The mortality rate was zero. The postoperative complication rate after delayed resection was higher than, but not significantly different from, that after simultaneous resection (46% vs. 23%, P=0.166). The duration of operating time (240 vs. 420 min, P<0.05) and postoperative hospital stay time (11 vs. 18 days, P<0.05) were shorter in the simultaneous resection group. After the initial treatments were given, the 1-, 2-, and 3-year survival rates in the simultaneous resection group were 77%, 59%, and 53%, respectively, whereas those in the delayed resection group were 67%, 42%, and 10%, respectively. The 5-year survival rate in the simultaneous resection group was 23%; overall survival differed significantly between the two groups (P=0.037). Median disease-free survival (DFS) times were 19.1 months in the simultaneous resection group and 8.8 months in the delayed resection group. DFS differed significantly between the two groups. CONCLUSIONS: Simultaneous colorectal and hepatic resection is safe and exhibits advantages in the long-time survival of patients.
format Online
Article
Text
id pubmed-5101227
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-51012272016-11-22 Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases Li, Yuan Bi, Xinyu Zhao, Jianjun Huang, Zhen Zhou, Jianguo Li, Zhiyu Zhang, Yefan Zhao, Hong Cai, Jianqiang Chin J Cancer Res Original Article OBJECTIVE: The safety of the simultaneous resection of synchronous colorectal cancer liver metastases (SCRLM) is still being debated. However, this simultaneous operative approach is more commonly adopted at present than in the past. Therefore, we compared simultaneous hepatic resection with delayed hepatic resection in this study. METHODS: All patients with SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included in our study. Short-term and long-term outcomes were compared in patients who underwent simultaneous colorectal and hepatic resection and those treated by delayed hepatectomy. RESULTS: Among the 73 patients diagnosed with SCRLM, simultaneous colorectal and hepatic resection was performed in 60 patients (82.2%), while delayed hepatic resection was performed in 13 patients (17.8%). The mortality rate was zero. The postoperative complication rate after delayed resection was higher than, but not significantly different from, that after simultaneous resection (46% vs. 23%, P=0.166). The duration of operating time (240 vs. 420 min, P<0.05) and postoperative hospital stay time (11 vs. 18 days, P<0.05) were shorter in the simultaneous resection group. After the initial treatments were given, the 1-, 2-, and 3-year survival rates in the simultaneous resection group were 77%, 59%, and 53%, respectively, whereas those in the delayed resection group were 67%, 42%, and 10%, respectively. The 5-year survival rate in the simultaneous resection group was 23%; overall survival differed significantly between the two groups (P=0.037). Median disease-free survival (DFS) times were 19.1 months in the simultaneous resection group and 8.8 months in the delayed resection group. DFS differed significantly between the two groups. CONCLUSIONS: Simultaneous colorectal and hepatic resection is safe and exhibits advantages in the long-time survival of patients. AME Publishing Company 2016-10 /pmc/articles/PMC5101227/ /pubmed/27877012 http://dx.doi.org/10.21147/j.issn.1000-9604.2016.05.08 Text en Copyright © 2016 Chinese Journal of Cancer Research. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Original Article
Li, Yuan
Bi, Xinyu
Zhao, Jianjun
Huang, Zhen
Zhou, Jianguo
Li, Zhiyu
Zhang, Yefan
Zhao, Hong
Cai, Jianqiang
Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases
title Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases
title_full Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases
title_fullStr Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases
title_full_unstemmed Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases
title_short Simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases
title_sort simultaneous hepatic resection benefits patients with synchronous colorectal cancer liver metastases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101227/
https://www.ncbi.nlm.nih.gov/pubmed/27877012
http://dx.doi.org/10.21147/j.issn.1000-9604.2016.05.08
work_keys_str_mv AT liyuan simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases
AT bixinyu simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases
AT zhaojianjun simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases
AT huangzhen simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases
AT zhoujianguo simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases
AT lizhiyu simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases
AT zhangyefan simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases
AT zhaohong simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases
AT caijianqiang simultaneoushepaticresectionbenefitspatientswithsynchronouscolorectalcancerlivermetastases