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Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives
Phosphorylation of the regulatory light chain (RLC) of myosin modulates cellular functions such as muscle contraction, mitosis, and cytokinesis. Phosphorylation defects are implicated in a number of diseases. Here we focus on striated muscle where changes in RLC phosphorylation relate to diseases su...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101276/ https://www.ncbi.nlm.nih.gov/pubmed/27084718 http://dx.doi.org/10.1007/s00249-016-1128-z |
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author | Yu, Haiyang Chakravorty, Samya Song, Weihua Ferenczi, Michael A. |
author_facet | Yu, Haiyang Chakravorty, Samya Song, Weihua Ferenczi, Michael A. |
author_sort | Yu, Haiyang |
collection | PubMed |
description | Phosphorylation of the regulatory light chain (RLC) of myosin modulates cellular functions such as muscle contraction, mitosis, and cytokinesis. Phosphorylation defects are implicated in a number of diseases. Here we focus on striated muscle where changes in RLC phosphorylation relate to diseases such as hypertrophic cardiomyopathy and muscular dystrophy, or age-related changes. RLC phosphorylation in smooth muscle and non-muscle cells are covered briefly where relevant. There is much scientific interest in controlling the phosphorylation levels of RLC in vivo and in vitro in order to understand its physiological function in striated muscles. A summary of available and emerging in vivo and in vitro methods is presented. The physiological role of RLC phosphorylation and novel pathways are discussed to highlight the differences between muscle types and to gain insights into disease processes. |
format | Online Article Text |
id | pubmed-5101276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-51012762016-11-21 Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives Yu, Haiyang Chakravorty, Samya Song, Weihua Ferenczi, Michael A. Eur Biophys J Review Phosphorylation of the regulatory light chain (RLC) of myosin modulates cellular functions such as muscle contraction, mitosis, and cytokinesis. Phosphorylation defects are implicated in a number of diseases. Here we focus on striated muscle where changes in RLC phosphorylation relate to diseases such as hypertrophic cardiomyopathy and muscular dystrophy, or age-related changes. RLC phosphorylation in smooth muscle and non-muscle cells are covered briefly where relevant. There is much scientific interest in controlling the phosphorylation levels of RLC in vivo and in vitro in order to understand its physiological function in striated muscles. A summary of available and emerging in vivo and in vitro methods is presented. The physiological role of RLC phosphorylation and novel pathways are discussed to highlight the differences between muscle types and to gain insights into disease processes. Springer Berlin Heidelberg 2016-04-15 2016 /pmc/articles/PMC5101276/ /pubmed/27084718 http://dx.doi.org/10.1007/s00249-016-1128-z Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Yu, Haiyang Chakravorty, Samya Song, Weihua Ferenczi, Michael A. Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives |
title | Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives |
title_full | Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives |
title_fullStr | Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives |
title_full_unstemmed | Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives |
title_short | Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives |
title_sort | phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101276/ https://www.ncbi.nlm.nih.gov/pubmed/27084718 http://dx.doi.org/10.1007/s00249-016-1128-z |
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