Acyclic nucleoside phosphonates containing the amide bond

ABSTRACT: To study the influence of a linker rigidity and donor–acceptor properties, the P–CH(2)–O–CHR– fragment in acyclic nucleoside phosphonates (e.g., acyclovir, tenofovir) was replaced by the P–CH(2)–HN–C(O)– residue. The respective phosphonates were synthesized in good yields by coupling the s...

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Detalles Bibliográficos
Autores principales: Głowacka, Iwona E., Piotrowska, Dorota G., Andrei, Graciela, Schols, Dominique, Snoeck, Robert, Wróblewski, Andrzej E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101293/
https://www.ncbi.nlm.nih.gov/pubmed/27881885
http://dx.doi.org/10.1007/s00706-016-1848-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101293/
https://www.ncbi.nlm.nih.gov/pubmed/27881885
http://dx.doi.org/10.1007/s00706-016-1848-x

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