STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

The local production of gamma interferon (IFN-γ) is important to control Toxoplasma gondii in the brain, but the basis for these protective effects is not fully understood. The studies presented here reveal that the ability of IFN-γ to inhibit parasite replication in astrocytes in vitro is dependent...

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Detalles Bibliográficos
Autores principales: Hidano, Shinya, Randall, Louise M., Dawson, Lucas, Dietrich, Hans K., Konradt, Christoph, Klover, Peter J., John, Beena, Harris, Tajie H., Fang, Qun, Turek, Bradley, Kobayashi, Takashi, Hennighausen, Lothar, Beiting, Daniel P., Koshy, Anita A., Hunter, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101356/
https://www.ncbi.nlm.nih.gov/pubmed/27834206
http://dx.doi.org/10.1128/mBio.01881-16
Descripción
Sumario:The local production of gamma interferon (IFN-γ) is important to control Toxoplasma gondii in the brain, but the basis for these protective effects is not fully understood. The studies presented here reveal that the ability of IFN-γ to inhibit parasite replication in astrocytes in vitro is dependent on signal transducer and activator of transcription 1 (STAT1) and that mice that specifically lack STAT1 in astrocytes are unable to limit parasite replication in the central nervous system (CNS). This susceptibility is associated with a loss of antimicrobial pathways and increased cyst formation in astrocytes. These results identify a critical role for astrocytes in limiting the replication of an important opportunistic pathogen.

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