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Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity
Although mast cells (MCs) have been discovered over 130 years ago, their function was almost exclusively linked to allergic affections. At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions. In the oral tissues, MCs release diffe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101369/ https://www.ncbi.nlm.nih.gov/pubmed/27847826 http://dx.doi.org/10.1155/2016/9235080 |
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author | Gaje, Pusa Nela Amalia Ceausu, Raluca Jitariu, Adriana Stratul, Stefan Ioan Rusu, Laura-Cristina Popovici, Ramona Amina Raica, Marius |
author_facet | Gaje, Pusa Nela Amalia Ceausu, Raluca Jitariu, Adriana Stratul, Stefan Ioan Rusu, Laura-Cristina Popovici, Ramona Amina Raica, Marius |
author_sort | Gaje, Pusa Nela |
collection | PubMed |
description | Although mast cells (MCs) have been discovered over 130 years ago, their function was almost exclusively linked to allergic affections. At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions. In the oral tissues, MCs release different proinflammatory cytokines, tumor necrosis factor alpha (TNF-α), that promote leukocyte infiltration in various inflammatory states of the oral cavity. These cells play a key role in the inflammatory process and, as a consequence, their number changes in different pathologic conditions of the oral cavity, like gingivitis, periodontitis, and so on. MCs also represent a rich source of proteases, especially of mast cell tryptase and chymase, which directly degrade the extracellular matrix through their proteolytic activity and thus indirectly stimulate angiogenesis and facilitate invasion and metastasis. It may be stated that mast cells could have an impact on primary tumor development, progression, and metastases in oral squamous cell carcinoma. By understanding the role of mast cells in the pathogenesis of different inflammatory and tumor diseases of the oral cavity, these cells may become therapeutic targets that could possibly improve the prognosis and survival of these patients. |
format | Online Article Text |
id | pubmed-5101369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51013692016-11-15 Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity Gaje, Pusa Nela Amalia Ceausu, Raluca Jitariu, Adriana Stratul, Stefan Ioan Rusu, Laura-Cristina Popovici, Ramona Amina Raica, Marius Biomed Res Int Review Article Although mast cells (MCs) have been discovered over 130 years ago, their function was almost exclusively linked to allergic affections. At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions. In the oral tissues, MCs release different proinflammatory cytokines, tumor necrosis factor alpha (TNF-α), that promote leukocyte infiltration in various inflammatory states of the oral cavity. These cells play a key role in the inflammatory process and, as a consequence, their number changes in different pathologic conditions of the oral cavity, like gingivitis, periodontitis, and so on. MCs also represent a rich source of proteases, especially of mast cell tryptase and chymase, which directly degrade the extracellular matrix through their proteolytic activity and thus indirectly stimulate angiogenesis and facilitate invasion and metastasis. It may be stated that mast cells could have an impact on primary tumor development, progression, and metastases in oral squamous cell carcinoma. By understanding the role of mast cells in the pathogenesis of different inflammatory and tumor diseases of the oral cavity, these cells may become therapeutic targets that could possibly improve the prognosis and survival of these patients. Hindawi Publishing Corporation 2016 2016-10-26 /pmc/articles/PMC5101369/ /pubmed/27847826 http://dx.doi.org/10.1155/2016/9235080 Text en Copyright © 2016 Pusa Nela Gaje et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gaje, Pusa Nela Amalia Ceausu, Raluca Jitariu, Adriana Stratul, Stefan Ioan Rusu, Laura-Cristina Popovici, Ramona Amina Raica, Marius Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity |
title | Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity |
title_full | Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity |
title_fullStr | Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity |
title_full_unstemmed | Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity |
title_short | Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity |
title_sort | mast cells: key players in the shadow in oral inflammation and in squamous cell carcinoma of the oral cavity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101369/ https://www.ncbi.nlm.nih.gov/pubmed/27847826 http://dx.doi.org/10.1155/2016/9235080 |
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