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Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands

The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148...

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Autores principales: Ayo, Christiane Maria, Frederico, Fábio Batista, Siqueira, Rubens Camargo, Brandão de Mattos, Cinara de Cássia, Previato, Mariana, Barbosa, Amanda Pires, Murata, Fernando Henrique Antunes, Silveira-Carvalho, Aparecida Perpétuo, de Mattos, Luiz Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101474/
https://www.ncbi.nlm.nih.gov/pubmed/27827450
http://dx.doi.org/10.1038/srep36632
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author Ayo, Christiane Maria
Frederico, Fábio Batista
Siqueira, Rubens Camargo
Brandão de Mattos, Cinara de Cássia
Previato, Mariana
Barbosa, Amanda Pires
Murata, Fernando Henrique Antunes
Silveira-Carvalho, Aparecida Perpétuo
de Mattos, Luiz Carlos
author_facet Ayo, Christiane Maria
Frederico, Fábio Batista
Siqueira, Rubens Camargo
Brandão de Mattos, Cinara de Cássia
Previato, Mariana
Barbosa, Amanda Pires
Murata, Fernando Henrique Antunes
Silveira-Carvalho, Aparecida Perpétuo
de Mattos, Luiz Carlos
author_sort Ayo, Christiane Maria
collection PubMed
description The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 149) of ocular scars/lesions due to toxoplasmosis. The group of patients with scars/lesions was further subdivided into two groups according to the type of ocular manifestation observed: primary (n = 120) or recurrent (n = 28). Genotyping was performed by PCR-SSOP. Statistical analyses were conducted using the Chi-square test, and odds ratio with a 95% confidence interval was also calculated to evaluate the risk association. The activating KIR3DS1 gene was associated with increased susceptibility for ocular toxoplasmosis. The activating KIR together with their HLA ligands (KIR3DS1-Bw4-80Ile and KIR2DS1(+)/C2(++) KIR3DS1(+)/Bw4-80Ile(+)) were associated with increased susceptibility for ocular toxoplasmosis and its clinical manifestations. KIR-HLA inhibitory pairs -KIR2DL3/2DL3-C1/C1 and KIR2DL3/2DL3-C1- were associated with decreased susceptibility for ocular toxoplasmosis and its clinical forms, while the KIR3DS1(−)/KIR3DL1(+)/Bw4-80Ile(+) combination was associated as a protective factor against the development of ocular toxoplasmosis and, in particular, against recurrent manifestations. Our data demonstrate that activating and inhibitory KIR genes may influence the development of ocular toxoplasmosis.
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spelling pubmed-51014742016-11-14 Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands Ayo, Christiane Maria Frederico, Fábio Batista Siqueira, Rubens Camargo Brandão de Mattos, Cinara de Cássia Previato, Mariana Barbosa, Amanda Pires Murata, Fernando Henrique Antunes Silveira-Carvalho, Aparecida Perpétuo de Mattos, Luiz Carlos Sci Rep Article The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 149) of ocular scars/lesions due to toxoplasmosis. The group of patients with scars/lesions was further subdivided into two groups according to the type of ocular manifestation observed: primary (n = 120) or recurrent (n = 28). Genotyping was performed by PCR-SSOP. Statistical analyses were conducted using the Chi-square test, and odds ratio with a 95% confidence interval was also calculated to evaluate the risk association. The activating KIR3DS1 gene was associated with increased susceptibility for ocular toxoplasmosis. The activating KIR together with their HLA ligands (KIR3DS1-Bw4-80Ile and KIR2DS1(+)/C2(++) KIR3DS1(+)/Bw4-80Ile(+)) were associated with increased susceptibility for ocular toxoplasmosis and its clinical manifestations. KIR-HLA inhibitory pairs -KIR2DL3/2DL3-C1/C1 and KIR2DL3/2DL3-C1- were associated with decreased susceptibility for ocular toxoplasmosis and its clinical forms, while the KIR3DS1(−)/KIR3DL1(+)/Bw4-80Ile(+) combination was associated as a protective factor against the development of ocular toxoplasmosis and, in particular, against recurrent manifestations. Our data demonstrate that activating and inhibitory KIR genes may influence the development of ocular toxoplasmosis. Nature Publishing Group 2016-11-09 /pmc/articles/PMC5101474/ /pubmed/27827450 http://dx.doi.org/10.1038/srep36632 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ayo, Christiane Maria
Frederico, Fábio Batista
Siqueira, Rubens Camargo
Brandão de Mattos, Cinara de Cássia
Previato, Mariana
Barbosa, Amanda Pires
Murata, Fernando Henrique Antunes
Silveira-Carvalho, Aparecida Perpétuo
de Mattos, Luiz Carlos
Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands
title Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands
title_full Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands
title_fullStr Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands
title_full_unstemmed Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands
title_short Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands
title_sort ocular toxoplasmosis: susceptibility in respect to the genes encoding the kir receptors and their hla class i ligands
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101474/
https://www.ncbi.nlm.nih.gov/pubmed/27827450
http://dx.doi.org/10.1038/srep36632
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