Lactate is a potent inhibitor of the capsaicin receptor TRPV1

Tissue ischemia results in an accumulation of lactate and local or systemic lactic acidosis. In nociceptive sensory neurons, lactate was reported to sensitize or activate the transient receptor potential ion channel TRPA1 and acid-sensing ion channels (ASICs). However, it is unclear how lactate modu...

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Detalles Bibliográficos
Autores principales: de la Roche, Jeanne, Walther, Isabella, Leonow, Waleria, Hage, Axel, Eberhardt, Mirjam, Fischer, Martin, Reeh, Peter W., Sauer, Susanne, Leffler, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101504/
https://www.ncbi.nlm.nih.gov/pubmed/27827430
http://dx.doi.org/10.1038/srep36740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101504/
https://www.ncbi.nlm.nih.gov/pubmed/27827430
http://dx.doi.org/10.1038/srep36740

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