Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections

A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in...

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Autores principales: Ottosson, H., Nylén, F., Sarker, P., Miraglia, E., Bergman, P., Gudmundsson, G. H., Raqib, R., Agerberth, B., Strömberg, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101518/
https://www.ncbi.nlm.nih.gov/pubmed/27827460
http://dx.doi.org/10.1038/srep36692
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author Ottosson, H.
Nylén, F.
Sarker, P.
Miraglia, E.
Bergman, P.
Gudmundsson, G. H.
Raqib, R.
Agerberth, B.
Strömberg, R.
author_facet Ottosson, H.
Nylén, F.
Sarker, P.
Miraglia, E.
Bergman, P.
Gudmundsson, G. H.
Raqib, R.
Agerberth, B.
Strömberg, R.
author_sort Ottosson, H.
collection PubMed
description A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD’s are promising candidates for treatment of infections.
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spelling pubmed-51015182016-11-14 Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections Ottosson, H. Nylén, F. Sarker, P. Miraglia, E. Bergman, P. Gudmundsson, G. H. Raqib, R. Agerberth, B. Strömberg, R. Sci Rep Article A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD’s are promising candidates for treatment of infections. Nature Publishing Group 2016-11-09 /pmc/articles/PMC5101518/ /pubmed/27827460 http://dx.doi.org/10.1038/srep36692 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ottosson, H.
Nylén, F.
Sarker, P.
Miraglia, E.
Bergman, P.
Gudmundsson, G. H.
Raqib, R.
Agerberth, B.
Strömberg, R.
Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections
title Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections
title_full Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections
title_fullStr Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections
title_full_unstemmed Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections
title_short Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections
title_sort potent inducers of endogenous antimicrobial peptides for host directed therapy of infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101518/
https://www.ncbi.nlm.nih.gov/pubmed/27827460
http://dx.doi.org/10.1038/srep36692
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