Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

BACKGROUND: Efflux transporters like MDR1 and MRP2 may modulate the pharmacokinetics of about 50 % of all drugs. It is currently unknown how much of the variation in the activities of important drug membrane transporters like MDR1 or MRP2 is determined by genetic or by environmental factors. In this...

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Detalles Bibliográficos
Autores principales: Matthaei, Johannes, Tzvetkov, Mladen V., Gal, Valerie, Sachse-Seeboth, Cordula, Sehrt, Daniel, Hjelmborg, Jakob B., Hofmann, Ute, Schwab, Matthias, Kerb, Reinhold, Brockmöller, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101708/
https://www.ncbi.nlm.nih.gov/pubmed/27825374
http://dx.doi.org/10.1186/s13073-016-0372-2

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