Latent pH-responsive ratiometric fluorescent cluster based on self-assembled photoactivated SNARF derivatives

We have developed a self-assembled fluorescent cluster comprising a seminaphthorhodafluor (SNARF) derivative protected by a photoremovable o-nitrobenzyl group. Prior to UV irradiation, a colorless and nonfluorescent cluster was spontaneously assembled in aqueous solution. After UV irradiation, the s...

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Detalles Bibliográficos
Autores principales: Nakata, Eiji, Yukimachi, Yoshihiro, Uto, Yoshihiro, Hori, Hitoshi, Morii, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Focus on Nanomedicine Molecular Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101900/
https://www.ncbi.nlm.nih.gov/pubmed/27877893
http://dx.doi.org/10.1080/14686996.2016.1204888
Descripción
Sumario:We have developed a self-assembled fluorescent cluster comprising a seminaphthorhodafluor (SNARF) derivative protected by a photoremovable o-nitrobenzyl group. Prior to UV irradiation, a colorless and nonfluorescent cluster was spontaneously assembled in aqueous solution. After UV irradiation, the self-assembled cluster remained intact and showed a large enhancement in pH-responsive fluorescence. The unique pH responsive fluorescent cluster could be used as a dual-emissive ratiometric fluorescent pH probe not only in the test tube but also in HeLa cell cultures.

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