An Ir(III) complex chemosensor for the detection of thiols

In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the comp...

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Detalles Bibliográficos
Autores principales: Mao, Zhifeng, Liu, Jinbiao, Kang, Tian-Shu, Wang, Wanhe, Han, Quan-Bin, Wang, Chun-Ming, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Bio-Inspired and Biomedical Materials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101911/
https://www.ncbi.nlm.nih.gov/pubmed/27877862
http://dx.doi.org/10.1080/14686996.2016.1162081
Descripción
Sumario:In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.

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