An Ir(III) complex chemosensor for the detection of thiols

In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Mao, Zhifeng, Liu, Jinbiao, Kang, Tian-Shu, Wang, Wanhe, Han, Quan-Bin, Wang, Chun-Ming, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Bio-Inspired and Biomedical Materials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101911/
https://www.ncbi.nlm.nih.gov/pubmed/27877862
http://dx.doi.org/10.1080/14686996.2016.1162081
_version_ 1782466376490811392
author Mao, Zhifeng
Liu, Jinbiao
Kang, Tian-Shu
Wang, Wanhe
Han, Quan-Bin
Wang, Chun-Ming
Leung, Chung-Hang
Ma, Dik-Lung
author_facet Mao, Zhifeng
Liu, Jinbiao
Kang, Tian-Shu
Wang, Wanhe
Han, Quan-Bin
Wang, Chun-Ming
Leung, Chung-Hang
Ma, Dik-Lung
author_sort Mao, Zhifeng
collection PubMed
description In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.
format Online
Article
Text
id pubmed-5101911
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-51019112016-11-22 An Ir(III) complex chemosensor for the detection of thiols Mao, Zhifeng Liu, Jinbiao Kang, Tian-Shu Wang, Wanhe Han, Quan-Bin Wang, Chun-Ming Leung, Chung-Hang Ma, Dik-Lung Sci Technol Adv Mater Bio-Inspired and Biomedical Materials In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids. Taylor & Francis 2016-04-06 /pmc/articles/PMC5101911/ /pubmed/27877862 http://dx.doi.org/10.1080/14686996.2016.1162081 Text en © 2016 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License CC-BYhttp://creativecommons.org/licenses/by/4.0/which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Bio-Inspired and Biomedical Materials
Mao, Zhifeng
Liu, Jinbiao
Kang, Tian-Shu
Wang, Wanhe
Han, Quan-Bin
Wang, Chun-Ming
Leung, Chung-Hang
Ma, Dik-Lung
An Ir(III) complex chemosensor for the detection of thiols
title An Ir(III) complex chemosensor for the detection of thiols
title_full An Ir(III) complex chemosensor for the detection of thiols
title_fullStr An Ir(III) complex chemosensor for the detection of thiols
title_full_unstemmed An Ir(III) complex chemosensor for the detection of thiols
title_short An Ir(III) complex chemosensor for the detection of thiols
title_sort ir(iii) complex chemosensor for the detection of thiols
topic Bio-Inspired and Biomedical Materials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101911/
https://www.ncbi.nlm.nih.gov/pubmed/27877862
http://dx.doi.org/10.1080/14686996.2016.1162081
work_keys_str_mv AT maozhifeng aniriiicomplexchemosensorforthedetectionofthiols
AT liujinbiao aniriiicomplexchemosensorforthedetectionofthiols
AT kangtianshu aniriiicomplexchemosensorforthedetectionofthiols
AT wangwanhe aniriiicomplexchemosensorforthedetectionofthiols
AT hanquanbin aniriiicomplexchemosensorforthedetectionofthiols
AT wangchunming aniriiicomplexchemosensorforthedetectionofthiols
AT leungchunghang aniriiicomplexchemosensorforthedetectionofthiols
AT madiklung aniriiicomplexchemosensorforthedetectionofthiols
AT maozhifeng iriiicomplexchemosensorforthedetectionofthiols
AT liujinbiao iriiicomplexchemosensorforthedetectionofthiols
AT kangtianshu iriiicomplexchemosensorforthedetectionofthiols
AT wangwanhe iriiicomplexchemosensorforthedetectionofthiols
AT hanquanbin iriiicomplexchemosensorforthedetectionofthiols
AT wangchunming iriiicomplexchemosensorforthedetectionofthiols
AT leungchunghang iriiicomplexchemosensorforthedetectionofthiols
AT madiklung iriiicomplexchemosensorforthedetectionofthiols

Ejemplares similares