Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis

Nonsteroidal antiinflammatory drugs, including ibuprofen, are among the most commonly used medications and produce their antiinflammatory effects by blocking cyclooxygenase (COX)-2. Their use is associated with increased risk of heart attacks caused by blocking COX-2 in the vasculature and/or kidney...

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Detalles Bibliográficos
Autores principales: Kirkby, Nicholas S., Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime H., Sampaio, Walkyria, Etelvino, Gisele, Leão, Nádia Miricéia, Santos, Robson A., Mitchell, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102117/
https://www.ncbi.nlm.nih.gov/pubmed/27601438
http://dx.doi.org/10.1096/fj.201600647R

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