A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca(2+) dysregulation and decrease in ATP levels

Small fiber neuropathy is a painful sensory nervous system disorder characterized by damage to unmyelinated C- and thinly myelinated Aδ- nerve fibers, clinically manifested by burning pain in the distal extremities and dysautonomia. The clinical onset in adulthood suggests a time-dependent process....

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Detalles Bibliográficos
Autores principales: Rolyan, Harshvardhan, Liu, Shujun, Hoeijmakers, Janneke GJ, Faber, Catharina G, Merkies, Ingemar SJ, Lauria, Giuseppe, Black, Joel A, Waxman, Stephen G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102167/
https://www.ncbi.nlm.nih.gov/pubmed/27821467
http://dx.doi.org/10.1177/1744806916674472

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