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Hyperpolarized (13)C Metabolic MRI of the Human Heart: Initial Experience
RATIONALE: Altered cardiac energetics is known to play an important role in the progression toward heart failure. A noninvasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism. OBJECTIVE:...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102279/ https://www.ncbi.nlm.nih.gov/pubmed/27635086 http://dx.doi.org/10.1161/CIRCRESAHA.116.309769 |
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author | Cunningham, Charles H. Lau, Justin Y.C. Chen, Albert P. Geraghty, Benjamin J. Perks, William J. Roifman, Idan Wright, Graham A. Connelly, Kim A. |
author_facet | Cunningham, Charles H. Lau, Justin Y.C. Chen, Albert P. Geraghty, Benjamin J. Perks, William J. Roifman, Idan Wright, Graham A. Connelly, Kim A. |
author_sort | Cunningham, Charles H. |
collection | PubMed |
description | RATIONALE: Altered cardiac energetics is known to play an important role in the progression toward heart failure. A noninvasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism. OBJECTIVE: To demonstrate the first hyperpolarized (13)C metabolic magnetic resonance imaging of the human heart. METHODS AND RESULTS: Four healthy subjects underwent conventional proton cardiac magnetic resonance imaging followed by (13)C imaging and spectroscopic acquisition immediately after intravenous administration of a 0.1 mmol/kg dose of hyperpolarized [1-(13)C]pyruvate. All subjects tolerated the procedure well with no adverse effects reported ≤1 month post procedure. The [1-(13)C]pyruvate signal appeared within the chambers but not within the muscle. Imaging of the downstream metabolites showed (13)C-bicarbonate signal mainly confined to the left ventricular myocardium, whereas the [1-(13)C]lactate signal appeared both within the chambers and in the myocardium. The mean (13)C image signal:noise ratio was 115 for [1-(13)C]pyruvate, 56 for (13)C-bicarbonate, and 53 for [1-(13)C]lactate. CONCLUSIONS: These results represent the first (13)C images of the human heart. The appearance of (13)C-bicarbonate signal after administration of hyperpolarized [1-(13)C]pyruvate was readily detected in this healthy cohort (n=4). This shows that assessment of pyruvate metabolism in vivo in humans is feasible using current technology. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02648009. |
format | Online Article Text |
id | pubmed-5102279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-51022792016-11-22 Hyperpolarized (13)C Metabolic MRI of the Human Heart: Initial Experience Cunningham, Charles H. Lau, Justin Y.C. Chen, Albert P. Geraghty, Benjamin J. Perks, William J. Roifman, Idan Wright, Graham A. Connelly, Kim A. Circ Res Brief UltraRapid Communication RATIONALE: Altered cardiac energetics is known to play an important role in the progression toward heart failure. A noninvasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism. OBJECTIVE: To demonstrate the first hyperpolarized (13)C metabolic magnetic resonance imaging of the human heart. METHODS AND RESULTS: Four healthy subjects underwent conventional proton cardiac magnetic resonance imaging followed by (13)C imaging and spectroscopic acquisition immediately after intravenous administration of a 0.1 mmol/kg dose of hyperpolarized [1-(13)C]pyruvate. All subjects tolerated the procedure well with no adverse effects reported ≤1 month post procedure. The [1-(13)C]pyruvate signal appeared within the chambers but not within the muscle. Imaging of the downstream metabolites showed (13)C-bicarbonate signal mainly confined to the left ventricular myocardium, whereas the [1-(13)C]lactate signal appeared both within the chambers and in the myocardium. The mean (13)C image signal:noise ratio was 115 for [1-(13)C]pyruvate, 56 for (13)C-bicarbonate, and 53 for [1-(13)C]lactate. CONCLUSIONS: These results represent the first (13)C images of the human heart. The appearance of (13)C-bicarbonate signal after administration of hyperpolarized [1-(13)C]pyruvate was readily detected in this healthy cohort (n=4). This shows that assessment of pyruvate metabolism in vivo in humans is feasible using current technology. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02648009. Lippincott Williams & Wilkins 2016-11-11 2016-11-10 /pmc/articles/PMC5102279/ /pubmed/27635086 http://dx.doi.org/10.1161/CIRCRESAHA.116.309769 Text en © 2016 The Authors. Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made. |
spellingShingle | Brief UltraRapid Communication Cunningham, Charles H. Lau, Justin Y.C. Chen, Albert P. Geraghty, Benjamin J. Perks, William J. Roifman, Idan Wright, Graham A. Connelly, Kim A. Hyperpolarized (13)C Metabolic MRI of the Human Heart: Initial Experience |
title | Hyperpolarized (13)C Metabolic MRI of the Human Heart: Initial Experience |
title_full | Hyperpolarized (13)C Metabolic MRI of the Human Heart: Initial Experience |
title_fullStr | Hyperpolarized (13)C Metabolic MRI of the Human Heart: Initial Experience |
title_full_unstemmed | Hyperpolarized (13)C Metabolic MRI of the Human Heart: Initial Experience |
title_short | Hyperpolarized (13)C Metabolic MRI of the Human Heart: Initial Experience |
title_sort | hyperpolarized (13)c metabolic mri of the human heart: initial experience |
topic | Brief UltraRapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102279/ https://www.ncbi.nlm.nih.gov/pubmed/27635086 http://dx.doi.org/10.1161/CIRCRESAHA.116.309769 |
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