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Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability

PURPOSE: To compare the respiratory and neurological outcomes at two years of age of preterm children born before 33 weeks of gestation (WG) after early preterm premature rupture of membranes (EPPROM) between 14 and 24 WG with preterm children without EPPROM. DESIGN AND PATIENTS: This single-center...

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Autores principales: Kieffer, Amelie, Pinto Cardoso, Gaelle, Thill, Caroline, Verspyck, Eric, Marret, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102432/
https://www.ncbi.nlm.nih.gov/pubmed/27829004
http://dx.doi.org/10.1371/journal.pone.0166130
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author Kieffer, Amelie
Pinto Cardoso, Gaelle
Thill, Caroline
Verspyck, Eric
Marret, Stéphane
author_facet Kieffer, Amelie
Pinto Cardoso, Gaelle
Thill, Caroline
Verspyck, Eric
Marret, Stéphane
author_sort Kieffer, Amelie
collection PubMed
description PURPOSE: To compare the respiratory and neurological outcomes at two years of age of preterm children born before 33 weeks of gestation (WG) after early preterm premature rupture of membranes (EPPROM) between 14 and 24 WG with preterm children without EPPROM. DESIGN AND PATIENTS: This single-center case-control retrospective study was conducted at Rouen University Hospital between 1(st) January 2000 and 31(st) December 2010. All the cases with EPPROM born from 26WG to 32WG were included. Each newborn was matched by sex, gestational age (GA) and year of birth to two very preterm children, born without EPPROM. At two years of corrected age, motor and cognitive abilities were assessed by routine score based on the Amiel-Tison and Denver developmental scales. RESULTS: Ninety-four cases with EPPROM before 24WG have been included. The 31 children born from 26WG to 32WG were matched with 62 controls. The EPPROM group had poorer clinical evaluation at one year for motor (p = 0.003) and cognitive developmental scores (p = 0.016). Neuromotor rehabilitation was performed more often (p = 0.013). However, there was no difference at 2 years of age. Children born after EPPROM were hospitalized more often for bronchiolitis (p<0.001) during their first 2 years, which correlates with increased incidence of pneumothorax (p = 0.017), pulmonary hypoplasia (p = 0.004) and bronchopulmonary dysplasia (p = 0.005) during neonatal period. CONCLUSION: At two years, despite an increase in severe bronchiolitis and the need for more neuromotor rehabilitation during the first month of the life after discharge, there was no difference in neurological outcomes in the very preterm children of the EPPROM group compared to those born at a similar GA without EPPROM.
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spelling pubmed-51024322016-11-18 Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability Kieffer, Amelie Pinto Cardoso, Gaelle Thill, Caroline Verspyck, Eric Marret, Stéphane PLoS One Research Article PURPOSE: To compare the respiratory and neurological outcomes at two years of age of preterm children born before 33 weeks of gestation (WG) after early preterm premature rupture of membranes (EPPROM) between 14 and 24 WG with preterm children without EPPROM. DESIGN AND PATIENTS: This single-center case-control retrospective study was conducted at Rouen University Hospital between 1(st) January 2000 and 31(st) December 2010. All the cases with EPPROM born from 26WG to 32WG were included. Each newborn was matched by sex, gestational age (GA) and year of birth to two very preterm children, born without EPPROM. At two years of corrected age, motor and cognitive abilities were assessed by routine score based on the Amiel-Tison and Denver developmental scales. RESULTS: Ninety-four cases with EPPROM before 24WG have been included. The 31 children born from 26WG to 32WG were matched with 62 controls. The EPPROM group had poorer clinical evaluation at one year for motor (p = 0.003) and cognitive developmental scores (p = 0.016). Neuromotor rehabilitation was performed more often (p = 0.013). However, there was no difference at 2 years of age. Children born after EPPROM were hospitalized more often for bronchiolitis (p<0.001) during their first 2 years, which correlates with increased incidence of pneumothorax (p = 0.017), pulmonary hypoplasia (p = 0.004) and bronchopulmonary dysplasia (p = 0.005) during neonatal period. CONCLUSION: At two years, despite an increase in severe bronchiolitis and the need for more neuromotor rehabilitation during the first month of the life after discharge, there was no difference in neurological outcomes in the very preterm children of the EPPROM group compared to those born at a similar GA without EPPROM. Public Library of Science 2016-11-09 /pmc/articles/PMC5102432/ /pubmed/27829004 http://dx.doi.org/10.1371/journal.pone.0166130 Text en © 2016 Kieffer et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kieffer, Amelie
Pinto Cardoso, Gaelle
Thill, Caroline
Verspyck, Eric
Marret, Stéphane
Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability
title Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability
title_full Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability
title_fullStr Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability
title_full_unstemmed Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability
title_short Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability
title_sort outcome at two years of very preterm infants born after rupture of membranes before viability
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102432/
https://www.ncbi.nlm.nih.gov/pubmed/27829004
http://dx.doi.org/10.1371/journal.pone.0166130
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