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Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease

BACKGROUND: Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases. OBJECTIVE: The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD). METHO...

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Autores principales: Montazerifar, Farzaneh, Bolouri, Ahmad, Paghalea, Raheleh Sharifian, Mahani, Mahbubeh Khodadadpour, Karajibani, Mansour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia - SBC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102481/
https://www.ncbi.nlm.nih.gov/pubmed/27627223
http://dx.doi.org/10.5935/abc.20160134
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author Montazerifar, Farzaneh
Bolouri, Ahmad
Paghalea, Raheleh Sharifian
Mahani, Mahbubeh Khodadadpour
Karajibani, Mansour
author_facet Montazerifar, Farzaneh
Bolouri, Ahmad
Paghalea, Raheleh Sharifian
Mahani, Mahbubeh Khodadadpour
Karajibani, Mansour
author_sort Montazerifar, Farzaneh
collection PubMed
description BACKGROUND: Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases. OBJECTIVE: The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD). METHODS: In a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity. RESULTS: CAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found. CONCLUSIONS: The findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results.
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spelling pubmed-51024812016-11-10 Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease Montazerifar, Farzaneh Bolouri, Ahmad Paghalea, Raheleh Sharifian Mahani, Mahbubeh Khodadadpour Karajibani, Mansour Arq Bras Cardiol Original Articles BACKGROUND: Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases. OBJECTIVE: The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD). METHODS: In a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls. Anthropometric measurements including weight and height for calculating of body mass index (BMI), and waist circumference (WC) were performed for evaluation of obesity. RESULTS: CAD patients had increased levels of leptin and CRP, (p < 0.001), cholesterol (p < 0.05), triglyceride (p < 0.01), and WC (p < 0.05) compared to healthy controls. There was no statistical difference between CAD and control subjects for resistin (p = 0.058). In a multiple regression analysis, only an association between serum leptin with BMI (β = 0.480, p < 0.05) and WC (β = 1.386, p < 0.05) was found. CONCLUSIONS: The findings suggest that leptin is a better marker of fat mass value than resistin and may be considered an independent risk factor for cardiac disorders that is largely dependent on obesity. However, further prospective studies are needed to confirm these results. Sociedade Brasileira de Cardiologia - SBC 2016-10 /pmc/articles/PMC5102481/ /pubmed/27627223 http://dx.doi.org/10.5935/abc.20160134 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Montazerifar, Farzaneh
Bolouri, Ahmad
Paghalea, Raheleh Sharifian
Mahani, Mahbubeh Khodadadpour
Karajibani, Mansour
Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_full Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_fullStr Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_full_unstemmed Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_short Obesity, Serum Resistin and Leptin Levels Linked to Coronary Artery Disease
title_sort obesity, serum resistin and leptin levels linked to coronary artery disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102481/
https://www.ncbi.nlm.nih.gov/pubmed/27627223
http://dx.doi.org/10.5935/abc.20160134
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